Upconversion nanothermometry: enabling high brightness in a thermal field

上转换纳米测温：在热场中实现高亮度

• 批准号: DE180100669
• 负责人: Prof Jiajia Zhou
• 金额: $ 24.04万
• 依托单位: University of Technology Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-06-01 至 2021-05-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE180100669
• 关键词: Upconversion; nanothermometry; enabling; brightness; thermal

This project aims to create a unique library of nanometer scale temperature-responsive sensors for bio-discoveries, disease diagnostics, device manufacturing and anti-counterfeiting, by investigating a new observation in enhanced photon energy conversion. The project will develop a thermal-field diagnostics approach to reveal interfacial cation-ligand behaviours of luminescent hybrid nanomaterials, and modify the otherwise quenching molecules to facilitate energy upconversion. This will link surface chemistry and heterogeneous interfacial physics. It will allow ratiometric fluorescence to achieve extremely high sensing sensitivity in intracellular nanothermometry, enabling super resolution thermal imaging of living cells.

该项目旨在通过研究增强光子能量转换的新观察，为生物发现，疾病诊断，设备制造和防伪创建一个独特的纳米级温度响应传感器库。该项目将开发一种热场诊断方法，以揭示发光混合纳米材料的界面阳离子-配体行为，并修改其他猝灭分子以促进能量上转换。这将连接表面化学和异质界面物理学。它将允许比率荧光在细胞内纳米测温中实现极高的传感灵敏度，从而实现活细胞的超分辨率热成像。