CRUI: Timing amd 3-Dimensional Analysis of Musculoskeletal Development

CRUI：肌肉骨骼发育的时机和 3 维分析

• 批准号: 9510228
• 负责人: Rafael de Sá
• 金额: $ 53.4万
• 依托单位: University of Richmond
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-15 至 1999-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9510228&HistoricalAwards=false
• 关键词: CRUI; Timing; amd; Dimensional; Analysis

This project is for Collaborative Research at Undergraduate Institutions, involving evolutionary and developmental biology, mathematics and computer sciences. One of the fundamental questions in biology is how variation in form arises from a general pattern common to a group of closely related species. Although a lot of descriptive detail is available about changes in shape and size of an animal during embryonic development, we lack precise and quantitative descriptions for irregular biological forms. This multidisciplinary approach will use new imaging technology ald recent advances in geometrical theory to establish some novel mathematical equations to characterize how the shape of a complex structure develops and evolves. The quantification of sizes and shapes of musculoskeletal structures in amphibians will be used to compare features at different times during development, and to compare features in evolutionarily related groups. The project brings together faculty and students from biology and computer science. Results will be important in interpreting how variation in timing of developmental events can be a mechanism for evolutionary change. This work has a potentially major impact on developmental and evolutionary biology, and promises a novel cross-disciplinary experience involving undergraduates in exciting research.

该项目适用于本科院校的合作研究，涉及进化和发育生物学、数学和计算机科学。 生物学的基本问题之一是，一组密切相关的物种所共有的一般模式如何产生形式变异。 尽管有很多关于胚胎发育过程中动物形状和大小变化的描述性细节，但我们缺乏对不规则生物形态的精确和定量描述。 这种多学科方法将使用新的成像技术和几何理论的最新进展来建立一些新颖的数学方程来表征复杂结构的形状如何发展和演变。 两栖动物肌肉骨骼结构的尺寸和形状的量化将用于比较发育过程中不同时间的特征，以及比较进化相关群体的特征。 该项目汇集了生物学和计算机科学领域的教师和学生。 结果对于解释发育事件时间的变化如何成为进化变化的机制非常重要。 这项工作对发育和进化生物学具有潜在的重大影响，并有望为本科生提供令人兴奋的研究的新颖的跨学科经验。