Asymmetric Catalysis in Supercritical Media

该奖项由环境友好的化学合成和加工项目颁发，并由环境保护局化学部门和污染预防和毒物办公室提供资金。此外，该项目还包括与康涅狄格州里奇菲尔德、勃林格-英格尔海姆公司和洛斯阿拉莫斯国家实验室的研究科学家合作。杜克大学化学系的马克·J·伯克将开发利用二氧化碳为基础的溶剂系统进行不对称催化反应的化学合成和加工技术。将研究不对称氢化、氢转移还原和羟醛缩合反应。化学工业使用大量的有机和氯化溶剂，这带来了严重的处置或回收问题。本项目将研究二氧化碳作为精细化学品生产的替代溶剂的效用。不对称催化是一种用于合成手性药物和农用化学品的方法，它为合成手性药物和农用化学品提供了一种获得对映体纯中间体的高效方法。在超临界二氧化碳中进行不对称催化有效地结合了两者的优势，以减少制造中的化学释放。

This award is made in the Environmentally Benign Chemical Synthesis and Processing program and is funded by the Division of Chemistry and the Office of Pollution Prevention and Toxics of the Environmental Protection Agency. In addition, the project includes collaboration with research scientists at the Ridgefield, Connecticut, laboratories of Boehringer Ingelheim Corporation and Los Alamos National Laboratories. Mark J. Burk of the Chemistry Department, Duke University, will develop chemical synthesis and processing technologies using carbon-dioxide based solvent systems for asymmetric catalytic reactions. Asymmetric hydrogenations, hydrogen transfer reductions, and aldol condensations will be investigated. Chemical industry uses large volumes of organic and chlorinated solvents which present serious disposal or recycling problems. The utility of carbon dioxide as a replacement solvent for the manufacture of fine chemicals will be examined in this project. Asymmetric catalysis is a method that offers energy-efficient access to enantiometrically pure intermediates for the synthesis of chiral drugs and agrochemicals. Performing asymmetric catalysis in supercritical carbon dioxide effectively combines the advantages of both to reduce chemical release in manufacturing.