Biomimetic Oxidation Chemistry

仿生氧化化学

• 批准号: 9521216
• 负责人: Cynthia Burrows
• 金额: $ 33.9万
• 依托单位: University of Utah
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-08-01 至 1998-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9521216&HistoricalAwards=false
• 关键词: Biomimetic; Oxidation; Chemistry

This grant from the Organic Dynamics Program supports the continuing research of Professor Cynthia Burrows at the University of Utah. Primary objectives are experiments on the site-specific metal catalyzed modification of DNA and other small molecules. Fundamental problems to be solved are the activation of dioxygen factors influencing the alkylation of DNA by nickel complexes and the dynamic parameters of nickel catalyzed oxidation of small molecules. Oxidation is a fundamental reaction in chemistry which when applied to organic and biological molecules can be useful as well as deleterious. It assists degradration and detoxification in some instances and it can initiate cancer in other conditions. Thus, a thorough understanding of these types of reactions is very important. This proposal addresses a specific aspect of the field wherein nickel facilitates the oxidation of DNA, a significant component of biological systems.

这项来自有机动力学项目的拨款支持了犹他大学辛西娅·巴罗斯教授的持续研究。主要目的是对特定位点的金属催化的DNA和其他小分子的修饰实验。需要解决的基本问题是影响DNA烷基化反应的双氧因子的活化和镍催化小分子氧化的动力学参数。氧化是化学中的一个基本反应，当应用于有机和生物分子时，它可能是有益的，也可能是有害的。在某些情况下，它有助于降解和解毒，在其他情况下，它可以引发癌症。因此，彻底了解这些类型的反应是非常重要的。该提案解决了该领域的一个特定方面，其中镍促进了生物系统的重要组成部分DNA的氧化。