H-Bonding Control of Molecular Self-Assembly

分子自组装的氢键控制

• 批准号: 9522162
• 负责人: Andrew Hamilton
• 金额: $ 26.75万
• 依托单位: University of Pittsburgh
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-07-01 至 1997-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9522162&HistoricalAwards=false
• 关键词: Bonding; Control; Molecular; Self; Assembly

The focus of this research is preparation and characterization of a series of molecules based upon hexameric aggregates of polycarboxylic acids that reproduce key features of biological self- assembly, including precise control of aggregation number, stability in different environments, formation of self-assembled substrate binding sites and the construction of functional aggregates. Large aggregates with nanometer scale dimensions, three dimensional aggregates with functional cavities and the formation of designed solids are further goals for the research. With this renewal award, the Synthetic Organic Program is supporting the research of Dr. Andrew D. Hamilton of the Department of Chemistry at the University of Pittsburgh. Professor Hamilton will focus his work on understanding the structural and functional basis of molecular self -assembly in both the solid and solution state. He will use synthetic molecules to mimic and probe the origins of biological order.

本研究的重点是制备和表征一种 一系列基于聚羧酸的六聚体聚集体的分子 酸能复制生物自组装的关键特征，包括 聚集数的精确控制，在不同条件下的稳定性 环境，自组装底物结合位点的形成和 功能性聚集体的构建。 纳米级大团聚体 尺度尺寸，具有功能腔的三维聚集体 以及设计实体的形成是研究的进一步目标。 有了这个更新奖，合成有机计划正在支持 安德鲁博士的研究。化学系的汉密尔顿说， 匹兹堡大学。 汉密尔顿教授将把工作重点放在 理解分子自我的结构和功能基础 - 在固态和溶液状态下组装。 他会用合成的 模拟和探索生物秩序的起源。