Carbanions and Physical Organic Chemistry

在有机动力学项目的资助下，Streitwieser教授在 加州大学伯克利分校将继续研究 极性有机金属试剂的反应动力学通过实验 以及理论化学，更深入地了解 控制这些复合物聚集的因素以及它们的相对分子质量。 反应将被收集。一个主要的问题仍然是 在这一领域，令研究人员困惑的是试剂的状态 聚集与反应性。本提案涉及这一问题。以来 这些试剂在有机合成中是普遍存在的， 让科学家能够预测 化学选择性和立体选择性将对 使用。 负责新方法的合成有机化学 并且生理活性化合物的实际制备依赖于 大量使用特定的试剂来实现某些有机转化。 这些试剂中的一些是复杂的并且具有多种形式。以来 确切的形式影响其反应效率，重要的是 了解影响这些试剂的因素。这项拟议的努力 将解决关于极性有机金属试剂的这些问题。

With funding from the Organic Dynamics Program, Professor Streitwieser at the University of California-Berkeley is to continue his studies on the reaction dynamics of polar organometallic reagents. Through experimental as well as theoretical chemistry, a more thorough understanding of the factors governing the aggregation of these complexes and their relative reactivities will be garnered. One of the major questions still confounding investigators in this area is the state of reagent aggregation versus reactivity. This proposal addresses this issue. Since these reagents are ubiquitous in organic synthesis, an understanding that allows scientists to predict the reactivity with regard to chemoselectivity and stereoselectivity would have significant impact on the use. Synthetic organic chemistry which is responsible for new methodologies and actual preparations of physiologically active compounds relies heavily on specific reagents to effect certain organic transformations. Some of these reagents are complex and have a variety of forms. Since the exact form affects the efficiency of its reactivity, it is important to understand the factors influencing these reagents. This proposed effort will address these issues with regard to polar organometallic reagents.