CAREER: Advancing Light-mediated Ni Catalysis using Data Science and Physical Organic Techniques

在化学部化学催化项目的资助下，加州大学河滨分校的Bahamonde博士将研究Ni/光氧化还原催化。基于Pd、Rh、Ir和Ru的过渡金属催化剂的稀缺性和高成本激发了人们对利用地球上丰富的过渡金属开发互补催化工艺的强烈兴趣。其中，Ni配合物独特的单电子化学和光化学反应性使得上述金属在很大程度上无法达到的新反应模式成为可能。为了在工业环境中实施这些新技术，进一步提高催化剂的性能和选择性至关重要。然而，目前，科学家们并不完全了解如何控制这些反应，以选择性地产生目标分子而不是竞争的副产物。在这个项目中，Bahamonde博士的目标是更深入地了解镍催化剂驱动这些反应的特征，并利用这些信息开发更具选择性的新催化剂。Bahamonde博士将积极参与建立在她的研究基础上的外展活动，以促进学生对科学、技术、工程和数学（STEM）学科的参与。这些活动，包括在Bahamonde博士实验室的暑期研究实习和在当地社区大学的网络活动，将旨在激发高中和社区大学生追求高等教育和STEM职业的兴趣。这个项目的研究将集中在Ni/光氧化还原催化上，特别强调理解有利于选择形成新的C-C和C-N键的配体特征。手性Ni配合物将用于探索对映选择性酰胺和C(sp3) -H功能化，以获得氮，α -杂原子和远程功能化。为了加速反应优化，将开发与观察到的对映体选择性相关的多元线性回归模型来计算分子描述符。了解什么配体特征可以促进选择性地访问这些可选流形中的任何一个也将被调查。Bahamonde博士将参与外展项目，重点是缩小STEM研究中的性别差距，将社区大学生转到四年制大学，以及高中生研究实习。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

With funding from the Chemical Catalysis Program of the Chemistry Division, Dr. Bahamonde of the University of California-Riverside will study Ni/photoredox catalysis. The scarcity and high cost of using transition metal catalysts based on Pd, Rh, Ir, and Ru has spurred intense interest in the development of complementary catalytic processes employing earth-abundant transition metals. Among these, the distinct one-electron chemistry and photochemical reactivity of Ni complexes has enabled new modes of reactivity that are largely inaccessible to the aforementioned metals. For the implementation of these new technologies in industrial settings, it is critical to further increase catalyst performance and selectivity. However, currently, scientists do not completely understand how these reactions can be controlled to selectively produce the target molecule over competing byproducts. In this project, Dr. Bahamonde aims to gain a deeper understanding of what Ni-catalyst features drive these reactions and use this information to develop new catalysts that are more selective. Dr. Bahamonde will actively engage in outreach activities that build upon her research to promote engagement of students in science, technology, engineering, and mathematics (STEM) disciplines. These activities, which include summer research internships in Dr. Bahamonde’s laboratory and networking events at local community colleges, will be directed at stimulating the interest of high school and community college students to pursue higher education and STEM careers. Research in this project will be focused on Ni/photoredox catalysis with a special emphasis on understanding the ligand features that favor the selective formation of new C–C and C–N bonds. Chiral Ni complexes will be utilized to explore enantioselective amide and C(sp3)–H functionalization in order to access nitrogen, alpha-heteroatom, and remote functionalizations. To expedite reaction optimization, multivariate linear regression models correlating observed enantioselectivity to compute molecular descriptors will be developed. Understanding what ligand characteristics can facilitate selective access to either of these alternative manifolds will be investigated as well. Dr. Bahamonde will engage in outreach programs focused on narrowing the gender gap in STEM research, the transfer of community college students to 4-year universities, and high school student research internships.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.