High Field NMR Study of Antitumor Active Platinum Complexes with Trans. Geometry

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This research focuses on activation of the trans geometry in platinum antitumor complexes, first studying the reactions of trans- PtCl2(NH3)(quinoline) with various nucleobases and nucleotides. Platinum (IV) analogs will be prepared and a careful comparison of platinum (II) and platinum (IV) reactivity with oligonucleotides will be undertaken using two dimensional and multinuclear nuclear magnetic resonance. Dr. Roat will also spend a summer research period in the Netherlands at Leiden University's Gorlaeus laboratories to continue research collaboration with Jane Rudijik. She will be accompanied by a graduate student from Virginia Commonwealth University and an undergraduate from Washington College. Interactive activities include: teaching an undergraduate/graduate level course in Bioinorganic Chemistry; organizing seminars for undergraduates, targeting women and minorities, devoted to putting together competitive applications for undergraduate and graduate research and academic scholarships and fellowships; and implementing a summer research exchange between host and home institution students with Leiden University, the Netherlands where Dr. Roat has extensive collaborative research contacts.