High Field NMR Study of Antitumor Active Platinum Complexes with Trans. Geometry

反式抗肿瘤活性铂配合物的高场核磁共振研究。

• 批准号: 9550387
• 负责人: Rosette Roat
• 金额: $ 9.28万
• 依托单位: Virginia Commonwealth University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-15 至 1996-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9550387&HistoricalAwards=false
• 关键词: Field; NMR; Study; Antitumor; Active

This research focuses on activation of the trans geometry in platinum antitumor complexes, first studying the reactions of trans- PtCl2(NH3)(quinoline) with various nucleobases and nucleotides. Platinum (IV) analogs will be prepared and a careful comparison of platinum (II) and platinum (IV) reactivity with oligonucleotides will be undertaken using two dimensional and multinuclear nuclear magnetic resonance. Dr. Roat will also spend a summer research period in the Netherlands at Leiden University's Gorlaeus laboratories to continue research collaboration with Jane Rudijik. She will be accompanied by a graduate student from Virginia Commonwealth University and an undergraduate from Washington College. Interactive activities include: teaching an undergraduate/graduate level course in Bioinorganic Chemistry; organizing seminars for undergraduates, targeting women and minorities, devoted to putting together competitive applications for undergraduate and graduate research and academic scholarships and fellowships; and implementing a summer research exchange between host and home institution students with Leiden University, the Netherlands where Dr. Roat has extensive collaborative research contacts.

本研究的重点是铂抗肿瘤配合物中反式几何构型的活化，首先研究了反式-PtCl_2（NH_3）（喹啉）与各种核碱基和核苷酸的反应。 将制备铂（IV）类似物，并使用二维和多核核磁共振仔细比较铂（II）和铂（IV）与寡核苷酸的反应性。 Roat博士还将在荷兰莱顿大学的Gorlaeus实验室度过一个夏季研究期，继续与Jane Rudijik进行研究合作。 陪同她的将是弗吉尼亚联邦大学的一名研究生和华盛顿学院的一名本科生。 互动活动包括：教授生物无机化学的本科生/研究生课程;组织针对妇女和少数民族的本科生研讨会，致力于为本科生和研究生研究以及学术奖学金和研究金提出竞争性申请;并与莱顿大学在寄宿学校和寄宿学校的学生之间进行夏季研究交流，Roat博士在荷兰有广泛的合作研究联系。