Genetic regulation of emotion regulation

情绪调节的基因调控

• 批准号: 100021859
• 负责人: Professor Dr. Henrik Walter
• 金额: --
• 依托单位: Abteilung für Psychologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2009
• 资助国家: 德国
• 起止时间: 2008-12-31 至 2014-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/100021859?language=en
• 关键词: Genetic; regulation; emotion

Although academic psychology is mainly occupied with researching psychological mechanisms or individual differences it is now commonly accepted that the functional organization of the brain is crucial for emotional information processing. In particular, imaging genetics has shown that it is possible to investigate genetically determined differences in emotional sensitivity. Accumulating evidence shows the involvement of amygdala and prefrontal regions and their interaction in emotion regulation processes. Moreover, reserach on the genetic regulation of emotion sensitivity has worked out the central role of polymorphisms in the serotonin(5-HTT)transporter gene and the catechol-O-methyltransferase(COMT)gene in emotion sensitivity. However, it is not known how psychological emotion regulation and genetic emotion regulation interact. In the proposed project we will investigate the influence of three different emotion regulation strategies on brain function. Futhermore, we will investigate the genetic influences on these psychological processes and the underlying neural mechanisms involved in emotion regulation.

虽然学术心理学主要研究心理机制或个体差异，但现在人们普遍认为，大脑的功能组织对情绪信息处理至关重要。特别是，成像遗传学已经表明，研究基因决定的情绪敏感性差异是可能的。越来越多的证据表明杏仁核和前额叶区域参与情绪调节过程及其相互作用。此外，情绪敏感性的遗传调控研究已经发现5-羟色胺（5-HTT）转运体基因和儿茶酚- o -甲基转移酶（COMT）基因多态性在情绪敏感性中的核心作用。然而，心理情绪调节和基因情绪调节如何相互作用尚不清楚。在本项目中，我们将研究三种不同的情绪调节策略对大脑功能的影响。此外，我们将探讨基因对这些心理过程的影响以及参与情绪调节的潜在神经机制。

项目成果

Common and differential neural networks of emotion regulation by Detachment, Reinterpretation, Distraction, and Expressive Suppression: A comparative fMRI investigation

• DOI: 10.1016/j.neuroimage.2014.06.051
• 发表时间: 2014-11-01
• 期刊: NEUROIMAGE
• 影响因子: 5.7
• 作者: Doerfel, Denise;Lamke, Jan-Peter;Walter, Henrik
• 通讯作者: Walter, Henrik

The Impact of Stimulus Valence and Emotion Regulation on Sustained Brain Activation: Task-Rest Switching in Emotion

• DOI: 10.1371/journal.pone.0093098
• 发表时间: 2014-03-28
• 期刊: PLOS ONE
• 影响因子: 3.7
• 作者: Lamke, Jan-Peter;Daniels, Judith K.;Walter, Henrik
• 通讯作者: Walter, Henrik

Studying the social dimension of emotion regulation

研究情绪调节的社会维度

• DOI: 10.3389/fpsyg.2013.00922
• 发表时间: 2014
• 期刊: Frontiers in Psychology
• 影响因子: 3.8
• 作者: Shuman V;Wagner U;Walter H;Scherer K (eds.)
• 通讯作者: Scherer K (eds.)