Genetic regulation of emotion regulation

虽然学术心理学主要致力于研究心理机制或个体差异，但现在普遍认为大脑的功能组织对情绪信息处理至关重要。特别是，成像遗传学已经表明，有可能调查基因决定的情绪敏感性差异。越来越多的证据表明，杏仁核和前额叶区域参与情绪调节过程及其相互作用。此外，情绪敏感性的遗传调控研究已发现5-羟色胺转运体（5-HTT）基因和儿茶酚氧位甲基转移酶（COMT）基因多态性在情绪敏感性中的核心作用。然而，目前还不知道心理情绪调节和遗传情绪调节如何相互作用。在这个项目中，我们将研究三种不同的情绪调节策略对大脑功能的影响。接下来，我们将研究遗传对这些心理过程的影响以及参与情绪调节的潜在神经机制。

Although academic psychology is mainly occupied with researching psychological mechanisms or individual differences it is now commonly accepted that the functional organization of the brain is crucial for emotional information processing. In particular, imaging genetics has shown that it is possible to investigate genetically determined differences in emotional sensitivity. Accumulating evidence shows the involvement of amygdala and prefrontal regions and their interaction in emotion regulation processes. Moreover, reserach on the genetic regulation of emotion sensitivity has worked out the central role of polymorphisms in the serotonin(5-HTT)transporter gene and the catechol-O-methyltransferase(COMT)gene in emotion sensitivity. However, it is not known how psychological emotion regulation and genetic emotion regulation interact. In the proposed project we will investigate the influence of three different emotion regulation strategies on brain function. Futhermore, we will investigate the genetic influences on these psychological processes and the underlying neural mechanisms involved in emotion regulation.