Renovation of Laboratory Space in the Chemistry Department for Biomolecular Research

分子水平上的科学技术进步为解决生物学和化学之间的关键问题提供了引人注目的新方法。这些进步很可能重新定义现有领域之间的界限，而跨传统学科的思想交叉施肥将允许在生物技术和先进分子材料方面发展新的成功合作。分子生物学方法在加州大学河滨分校化学系的几个研究实验室中得到了应用。然而，教师分散在皮尔斯大厅内的许多地方，其中化学空间于1965年建成。在无机化学、生物材料化学、受体-配体结合化学、合成有机化学和核酸化学等领域，该建筑缺乏必要的核心设施。NSF和UCR将建立合作伙伴关系，以开发所需的研究基础设施，为跨越化学传统边界的合作努力的扩展和发展提供物理重点。改善皮尔斯大厅的研究基础设施将包括改造三楼的21个研究实验室空间。翻新包括：石棉减少，拆除不符合规范的通风柜，水槽和工作台，升级公用事业系统，包括额外的电力，蒸汽和工业热水，修复HVAC，燃气，真空和管道管道，以及安装柜，通风柜和橱柜。共同使用的核心设施包括冷藏室、离心室、多功能仪器室、3级重组DNA设施和热实验室。该项目补充了之前在Pierce Hall的ARI冷冻水项目，将直接提升5名高级人员、8名博士后、20名研究生和11名本科生的研究前景。拥有现代化的设施将为在化学-生物学界面有研究兴趣的学生提供更多的研究训练机会。由于这所大学的少数族裔学生比例是加州大学所有校区中最高的，女性占加州大学r学生总数的52%以上，因此这个项目将对这些群体的个人进入物理科学的招聘产生影响，而这两个群体的代表性都严重不足。

Scientific and technological advances at the molecular level are providing dramatic new approaches to address critical problems at the interface between biology and chemistry. These advances may well redefine current boundaries between existing fields, and cross fertilization of ideas across traditional disciplines will allow the development of new successful collaborations in biotechnology and advanced molecular materials. Molecular biological approaches are used in several research laboratories in the chemistry department at the University of California - Riverside (UCR). However, faculty are dispersed in many locations within Pierce Hall, in which space for chemistry was constructed in 1965. The building lacks certain core facilities necessary for the conduction of faculty research in the following areas: inorganic chemistry, chemistry of biomaterials, receptor-ligand binding chemistry, synthetic organic chemistry, and nucleic acid chemistry. A partnership between the NSF and UCR will be established to develop the required research infrastructure to provide a physical focus for extension and development of collaborative efforts across tradition boundaries in chemistry. Improving the research infrastructure in Pierce Hall will involve the renovation of 21 research laboratory spaces on the third floor. Renovations include: asbestos abatement, removal of non-code compliant fume hood, sinks, and benchwork, upgrade of utility systems to include additional power, steam and industrial hot water, reconditioning of HVAC, gas, vacuum and plumbing lines, and the installation of casework, fume hoods, and cabinets. Joint-use core facilities including cold rooms, a centrifuge room, multipurpose instrumentation rooms, a Level 3 recombinant DNA facility and a hot lab will be created. This project, complementing a previous ARI Chilled Water Project in Pierce Hall, will directly enhance the research prospects for five senior personnel, eight postdocs, twenty graduate students and eleven undergraduate students. Having modern facilities will improve research training opportunities for students with research interests at the Chemistry-Biology interface. Since the university has the largest percentage of minority students of any UC campus, and women comprise over 52% of the UCR student body, this project will have an impact on the recruitment of these groups of individuals into the physical sciences where both are seriously underrepresented.