Upgrade of NMR Instrumentation in a College Wide Facility

大学设施中核磁共振仪器的升级

• 批准号: 9724392
• 负责人: William Okamura
• 金额: $ 30万
• 依托单位: University of California-Riverside
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 1999-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9724392&HistoricalAwards=false
• 关键词: Upgrade; NMR; Instrumentation; College; Wide

This award from the Chemistry Research Instrumentation and Facilities (CRIF) Program and the Major Research Instrumentation (MRI) Program and the Office of Multidisciplinary Activities (OMA) will assist the Department of Chemistry at University of California @ Riverside to upgrade a 300 MHz and a 500 MHz NMR Spectrometer. This equipment will enhance research in a number of areas including the following: (1) total synthesis of natural products, (2) NMR characterization of pollutant transport through porous media, (3) structure-function played by H-bonded protons with large H-chemical shifts in the insulin hexamer, (4) conformation analysis and the relationship to biological activity, (5) stereochemistry of side chain crosslinking in peptides and proteins, and (6) synthesis, structural and biological studies of biomedically significant natural products. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometry is essential to chemists who are carrying out frontier research. The results from these NMR studies are useful in the areas such as polymers, catalysis, and in biology.

这份来自化学研究仪器和设施（CRIF）项目、主要研究仪器（MRI）项目和多学科活动办公室（OMA）的合同将协助加州大学河滨分校化学系升级一台300 MHz和500 MHz核磁共振光谱仪。这种设备将加强若干领域的研究，包括：(1)天然产物的全合成；(2)污染物在多孔介质中运移的核磁共振表征；(3)胰岛素六聚体中具有大h化学位移的氢键质子的结构-功能；(4)构象分析及其与生物活性的关系；(5)多肽和蛋白质侧链交联的立体化学；(6)具有生物医学意义的天然产物的合成、结构和生物学研究。核磁共振（NMR）波谱是化学家用来阐明分子结构的最有力的工具。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。获得最先进的核磁共振光谱是必不可少的化学家谁正在进行前沿研究。这些核磁共振研究的结果在聚合物、催化和生物学等领域是有用的。