Renovation of Wistar Structural Biology Macromolecular Interactions Complex

Wistar结构生物学大分子相互作用复合物的改造

• 批准号: 9602834
• 负责人: David Speicher
• 金额: $ 26.71万
• 依托单位: Wistar Institute
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-11-01 至 1998-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9602834&HistoricalAwards=false
• 关键词: Renovation; Wistar; Structural; Biology; Macromolecular

The Wistar Institute, founded in 1892, is the oldest independent institution in the United States devoted to biological research and training. Located in close proximity to the University of Pennsylvania, the Institute has developed collaborative interactions with the university while maintaining its status as an independent, nonprofit, basic research organization. Thirty-eight laboratories are housed in the facility, including research laboratories for the Structural Biology Program, established in 1991. An important aim of the Program is to develop and apply technologies and methodological approaches to investigate biological macromolecules at every level of organization, ranging from atomic detail using X-ray crystallography and NMR spectroscopy to complex macromolecule assemblies. Existing conditions of the facility prevent the optimal usage of space and specialized equipment contained in laboratories designated to accomplish this work. Problems include: major deficiencies in the air condition system, including inadequate cooling, dehumidification, and temperature fluctuations; 2) unreliable cold room space; 3) poor layout and space design, and 4) inadequate plumbing that periodically floods the lab damaging equipment. The ARI Program will provide funds to rectify deficiencies of space dedicated for the Macromolecular Interaction Complex of the Structural Biology Program. Specifically, four laboratories will be consolidated in contiguous space that can be designed for structure-function and biochemical studies and for required instrumentation. The renovated space will facilitate interactions with investigators and students, and will support advanced technologies needed to conduct modern molecular biology research. This project also complements the renovation of the Macromolecular Structure Facility, a project that was partially funded by the ARI Program.

Wistar研究所成立于1892年，是美国致力于生物研究和培训的最古老的独立机构。该研究所位于宾夕法尼亚大学附近，在保持其独立、非营利性基础研究机构地位的同时，与宾夕法尼亚大学开展了合作互动。该设施内有38个实验室，包括1991年建立的结构生物学项目的研究实验室。该计划的一个重要目标是开发和应用技术和方法来研究生物大分子的各个组织水平，从使用x射线晶体学和核磁共振光谱的原子细节到复杂的大分子组装。该设施的现有条件阻碍了对实验室空间和专用设备的最佳利用，这些实验室被指定用于完成这项工作。问题包括：空调系统存在重大缺陷，如制冷、除湿不足、温度波动等；2)冷室空间不可靠；3)不良的布局和空间设计，4)不充分的管道，定期淹没实验室损坏设备。ARI计划将提供资金，以纠正结构生物学计划的大分子相互作用复合体的空间不足。具体来说，四个实验室将合并在连续的空间中，可以设计用于结构功能和生化研究以及所需的仪器。翻新后的空间将促进与研究人员和学生的互动，并将支持进行现代分子生物学研究所需的先进技术。该项目还补充了大分子结构设施的改造，该项目部分由ARI计划资助。