REU Site: Molecular Basis of Cellular Phenotypes (MBCP) at The Wistar Institute

REU 网站：Wistar 研究所的细胞表型分子基础 (MBCP)

• 批准号: 2150060
• 负责人: David Zuzga
• 金额: $ 41.61万
• 依托单位: Wistar Institute
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-01 至 2026-01-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2150060&HistoricalAwards=false
• 关键词: REU; Site; Molecular; Basis; Cellular

This REU Site award to Wistar Institute located in Philadelphia, PA, will support the training of 10 students for 10 weeks during the summers of 2023-2025. It is anticipated that a total of 30 students, primarily from schools with limited research opportunities or from an under-represented group, will be trained in the program. Students will learn how research is conducted, and many will present the results of their work at scientific conferences. The program will provide students with research experience, mentorship, and professional support to help them embark on successful graduate careers in the life sciences and will support a diverse pipeline of future life scientists. Assessment of the program will be done through an online system. Students will be tracked after the program to determine their career paths.The Molecular Basis of Cellular Phenotypes REU Program is organized around one of the NSF’s 10 Big Ideas, “Understanding the Rules of Life,” and is aligned with its aim to elucidate the sets of rules that predict an organism's observable characteristics, its phenotype. Projects explore molecular function to understand cell behavior. Faculty mentors from each of Wistar’s research programs: Gene Expression & Regulation; Immunology, Microenvironment & Metastasis; Molecular & Cellular Oncogenesis; and Vaccine & Immunotherapy will offer exciting projects for undergraduates. The program consists of a 2-week lab orientation designed to increase student confidence and productivity, followed by an 8-week internship. During orientation, students participate in hands-on training in molecular and cellular biology techniques and investigate how genetic variation in the human TP53 gene affect cellular outcomes (for example, apoptosis). Based on their scientific interests, students are then assigned an internship project and a predoctoral trainee to serve as a peer mentor to enhance their sense of belonging within Wistar’s research community. Professional and personal growth is supported by cohort-building activities and weekly group workshops with topics covering science communication, responsible conduct of research training, and graduate school application. More information about the program is available by visiting https://wistar.org/education-training or by contacting the PI (Dr. David Zuzga at [e-mail]) or the co-PI (Dr. Kristy Shuda McGuire at [e-mail]).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

位于宾夕法尼亚州费城的Wistar研究所的REU网站奖将在2023-2025年夏季支持10名学生的10周培训。预计共有30名学生，主要来自研究机会有限的学校或代表性不足的群体，将在该方案中接受培训。学生将学习如何进行研究，许多人将在科学会议上展示他们的工作成果。该计划将为学生提供研究经验，指导和专业支持，以帮助他们在生命科学领域成功地开展研究生职业生涯，并将支持未来生命科学家的多元化管道。对该方案的评估将通过一个在线系统进行。学生将在课程结束后进行跟踪，以确定他们的职业道路。细胞表型的分子基础REU课程围绕NSF的10大理念之一“理解生命的规则”组织，并与其目标相一致，即阐明预测生物体可观察特征的规则集，其表型。项目探索分子功能以了解细胞行为。来自Wistar每个研究项目的教师导师：基因表达调控;免疫学，微环境转移;分子细胞肿瘤发生;和疫苗免疫治疗将为本科生提供令人兴奋的项目。该计划包括为期2周的实验室培训，旨在提高学生的信心和生产力，然后是为期8周的实习。在定向过程中，学生参加分子和细胞生物学技术的实践培训，并研究人类TP 53基因的遗传变异如何影响细胞结果（例如，细胞凋亡）。 根据他们的科学兴趣，学生们被分配一个实习项目和一名博士前实习生作为同行导师，以增强他们在Wistar研究社区的归属感。专业和个人的成长是由队列建设活动和每周小组研讨会的主题涵盖科学传播，负责任的研究培训行为，和研究生院申请的支持。有关该计划的更多信息，请访问https://wistar.org/education-training或联系PI（大卫Zuzga博士，[e-mail]）或联合PI（Kristy Shuda McGuire博士，[e-mail]）。该奖项反映了NSF的法定使命，并被认为值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估来支持。