U.S.-France Cooperative Research: Probing the Dynamics of Ribozymes by 13C NMR Relaxation

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This three-year award supports U.S.-France cooperative research in molecular biochemistry between Arthur Pardi of the University of Colorado and Dominique Marion of the Structural Biology Institute at the French National Center for Scientific Research. The project also provides travel support for a postdoctoral researcher and graduate student. The objective of the research is to probe the dynamics of proteins in solutions by applying NMR relaxation techniques developed by the French laboratory. This project takes advantage of French expertise and will advance understanding of the role of dynamics in site-specific cleavage of RNA substrates by ribozymes.