A Mass Spectrometric Approach to the Chemical Assay Problem of Combinatorial Libraries

这个探索性研究（SGER）的小补助金是在分析和表面化学程序的支持。 在为期十二个月的标准拨款期间，Winograd教授及其在宾夕法尼亚州立大学的研究小组将探索使用飞行时间二次离子质谱（TOF-SIMS）方法对组合库进行化学分析的可行性。 TOF-SIMS方法的分子特异性，结合光栅离子束的二维空间分辨率，将用于分析在梅里菲尔德珠基质上形成的组合文库。 这一奋进的成功将提高此类文库的分析速度，并加速组合合成方法领域的进展。 飞行时间二次离子质谱是一种非常强大的分子鉴定和定量技术。 光栅离子束技术的加入增加了这种分析能力的二维空间分辨率，并提出了一种快速分析由组合合成方法产生的化合物“库”的方法。 宾夕法尼亚州立大学的Nicholas Winograd教授和他的学生将在探索性研究小额赠款的支持下确定这种分析方法的可行性。 成功的组合库分析策略的发展将有助于显着地推进这一领域的合成化学。

This Small Grant for Exploratory Research (SGER) is supported in the Analytical and Surface Chemistry Program. During the tenure of this twelve-month standard grant, Professor Winograd and his research group at the Pennsylvania State University will explore the feasibility of using time-of-flight secondary ion mass spectrometry (TOF-SIMS) methods for the chemical analysis of combinatorial libraries. The molecular specificity of TOF-SIMS methods, coupled with the two-dimensional spatial resolution of a rastered ion beam, will be used to analyze combinatorial libraries formed on Merrifield bead substrates. Success in this endeavor will enhance the speed with which such libraries can be analyzed and accelerate progress in the area of combinatorial methods of synthesis. Time-of-flight secondary ion mass spectrometry is an extremely powerful technique for molecular identification and quantification. The inclusion of rastered ion beam technology adds two-dimensional spatial resolution to this analytical capability and suggests a method for the rapid analysis of `libraries` of chemical compounds produced by combinatorial synthetic methods. Professor Nicholas Winograd and his students at Penn State University will determine the feasibility of this analytical approach with support from this Small Grant for Exploratory Research. The development of successful strategies for combinatorial library analysis will assist markedly in the advancement of this area of synthetic chemistry.