A Mass Spectrometric Approach to the Chemical Assay Problem of Combinatorial Libraries

这项用于探索性研究的小资助金(SGER)得到了分析和表面化学计划的支持。在这项为期12个月的标准拨款期间，宾夕法尼亚州立大学的Winograd教授和他的研究小组将探索使用飞行时间二次离子质谱仪(TOF-SIMS)方法对组合图书馆进行化学分析的可行性。TOF-SIMS方法的分子专一性与栅状离子束的二维空间分辨率相结合，将被用于分析在Merrifield珠基上形成的组合库。这一努力的成功将提高分析这类文库的速度，并加速合成组合方法领域的进展。飞行时间二次离子质谱仪是一种非常强大的分子鉴定和定量技术。栅状离子束技术的加入增加了这种分析能力的二维空间分辨率，并提出了一种快速分析组合合成方法产生的化合物的“库”的方法。宾夕法尼亚州立大学的尼古拉斯·维诺格拉德教授和他的学生将在探索性研究小额拨款的支持下，确定这种分析方法的可行性。成功的组合文库分析策略的发展将大大促进合成化学这一领域的发展。

This Small Grant for Exploratory Research (SGER) is supported in the Analytical and Surface Chemistry Program. During the tenure of this twelve-month standard grant, Professor Winograd and his research group at the Pennsylvania State University will explore the feasibility of using time-of-flight secondary ion mass spectrometry (TOF-SIMS) methods for the chemical analysis of combinatorial libraries. The molecular specificity of TOF-SIMS methods, coupled with the two-dimensional spatial resolution of a rastered ion beam, will be used to analyze combinatorial libraries formed on Merrifield bead substrates. Success in this endeavor will enhance the speed with which such libraries can be analyzed and accelerate progress in the area of combinatorial methods of synthesis. Time-of-flight secondary ion mass spectrometry is an extremely powerful technique for molecular identification and quantification. The inclusion of rastered ion beam technology adds two-dimensional spatial resolution to this analytical capability and suggests a method for the rapid analysis of `libraries` of chemical compounds produced by combinatorial synthetic methods. Professor Nicholas Winograd and his students at Penn State University will determine the feasibility of this analytical approach with support from this Small Grant for Exploratory Research. The development of successful strategies for combinatorial library analysis will assist markedly in the advancement of this area of synthetic chemistry.