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GRK 1591: Posttranscriptional Control of Gene Expression: Mechanisms and Role in Pathogenesis

GRK 1591：基因表达的转录后控制：发病机制和作用

基本信息

批准号：
105533105
负责人：
金额：
--
依托单位：
Martin-Luther-Universität Halle-Wittenberg
依托单位国家：
德国
项目类别：
Research Training Groups
财政年份：
2010
资助国家：
德国
起止时间：
2009-12-31 至 2018-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/105533105?language=en
关键词：
GRK 1591 Posttranscriptional Control Gene

项目摘要

Gene expression is controlled at the transcriptional as well as posttranscriptional level. Posttranscriptional control is essentially determined by the regulation of mRNA turnover, translation or the directed subcellular transport of specific transcripts. Major regulators of these processes are RNA binding proteins (RBPs) and non-coding RNAs, in particular microRNAs (miRNAs, miRs) in higher eukaryotes as well as small non-coding sRNAs in bacteria. Currently, major research efforts aim at elucidating the role of posttranscriptional control by RNA binding proteins and small non-coding RNAs in pathobiological processes. Research in this field essentially relies on translational approaches and addresses various aspects of immediate clinical relevance. Accordingly, structured programmes aiming at the training of graduates in associated disciplines are required. Aspects of posttranscriptional control of gene expression are a central research focus at the Martin Luther University (MLU). Research efforts in this field are essentially promoted by this Research Training Group that provides a structured and interdisciplinary educational framework for the training of PhDs as well as MDs. These efforts are supported by close collaborations and cooperation between the faculties of natural sciences and medicine at the MLU. In accord with the educational programme, research efforts of the Research Training Group aim at analysing molecular mechanisms directing posttranscriptional control of mRNA fate and elucidating how their deregulation promotes pathogenesis. Along these lines, the Research Training Group characterises distinct molecular determinants of posttranscriptional control. These include enzymes, cytoskeletal proteins, RNA binding proteins, microRNAs, siRNAs as well as sRNAs. Research and educational efforts of the Research Training Group are supported by a broad expertise spectrum of associated scientists covering biochemistry, molecular biology, cell biology, biomedicine and clinical practice.

基因表达在转录和转录后水平受到控制。转录后控制基本上是由mRNA周转、翻译或特定转录物的定向亚细胞转运的调控决定的。这些过程的主要调控因子是RNA结合蛋白（rbp）和非编码RNA，特别是高等真核生物中的微RNA （miRNAs, miRs）以及细菌中的小非编码sRNAs。目前，主要的研究工作旨在阐明RNA结合蛋白和小非编码RNA在病理生物学过程中的转录后控制作用。该领域的研究基本上依赖于转化方法，并涉及直接临床相关的各个方面。因此，需要有组织的方案，旨在培训相关学科的毕业生。基因表达的转录后控制方面是马丁·路德大学（MLU）的中心研究重点。这一领域的研究工作主要是由研究培训小组推动的，该小组为博士和博士的培训提供了一个结构化的跨学科教育框架。这些努力得到了罗马国立大学自然科学学院和医学院之间密切合作的支持。根据教育计划，研究培训小组的研究工作旨在分析指导mRNA转录后命运控制的分子机制，并阐明其解除调控如何促进发病机制。沿着这些思路，研究训练组的特征转录后控制的不同分子决定因素。这些包括酶，细胞骨架蛋白，RNA结合蛋白，microrna， sirna以及srna。研究培训小组的研究和教育工作得到了广泛的专业知识范围的相关科学家的支持，包括生物化学，分子生物学，细胞生物学，生物医学和临床实践。