GRK 1591: Posttranscriptional Control of Gene Expression: Mechanisms and Role in Pathogenesis

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Gene expression is controlled at the transcriptional as well as posttranscriptional level. Posttranscriptional control is essentially determined by the regulation of mRNA turnover, translation or the directed subcellular transport of specific transcripts. Major regulators of these processes are RNA binding proteins (RBPs) and non-coding RNAs, in particular microRNAs (miRNAs, miRs) in higher eukaryotes as well as small non-coding sRNAs in bacteria. Currently, major research efforts aim at elucidating the role of posttranscriptional control by RNA binding proteins and small non-coding RNAs in pathobiological processes. Research in this field essentially relies on translational approaches and addresses various aspects of immediate clinical relevance. Accordingly, structured programmes aiming at the training of graduates in associated disciplines are required. Aspects of posttranscriptional control of gene expression are a central research focus at the Martin Luther University (MLU). Research efforts in this field are essentially promoted by this Research Training Group that provides a structured and interdisciplinary educational framework for the training of PhDs as well as MDs. These efforts are supported by close collaborations and cooperation between the faculties of natural sciences and medicine at the MLU. In accord with the educational programme, research efforts of the Research Training Group aim at analysing molecular mechanisms directing posttranscriptional control of mRNA fate and elucidating how their deregulation promotes pathogenesis. Along these lines, the Research Training Group characterises distinct molecular determinants of posttranscriptional control. These include enzymes, cytoskeletal proteins, RNA binding proteins, microRNAs, siRNAs as well as sRNAs. Research and educational efforts of the Research Training Group are supported by a broad expertise spectrum of associated scientists covering biochemistry, molecular biology, cell biology, biomedicine and clinical practice.