Collaborative: The Role of Gene Duplication in the Evolution of Chordate Developmental Regulation

合作：基因复制在脊索动物发育调控进化中的作用

• 批准号: 9614940
• 负责人: Chris Amemiya
• 金额: $ 16.26万
• 依托单位: Trustees of Boston University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-08-01 至 1999-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9614940&HistoricalAwards=false
• 关键词: Collaborative; Role; Gene; Duplication; Evolution

9614940 Amemiya The Hox genes exist as highly conserved gene clusters within the chordates. The protochordate, Amphioxus, has a single gene cluster, while the mammals, birds, and fishes have four. The Hox genes play an important role in embryogenesis, specifying developmental identities along the anterior/posterior axis. Drs. Ruddle, Wagner, and Amemiya will determine by direct testing whether intermediate forms such as cyclostomes and elasmobranchs have intermediate cluster numbers and whether cluster duplication occurred once or several times independently during Chordate evolution. They will also determine whether different clades posses different Hox gene numbers, and if the loss or gain of genes has been the same or different. Differences and similarities in Hox gene composition will be correlated with the developmental status of the different species examined. They will study particular Hox orthologous genes in detail, especially examining similarities and differences in enhancer structure and function on a comparative basis. By these approaches, they hope to better understand the relationship between developmental regulation and evolutionary process.

小行星9614940 Hox基因作为高度保守的基因簇存在于脊索动物中。 原脊索动物文昌鱼只有一个基因簇，而哺乳动物、鸟类和鱼类则有四个。 Hox基因在胚胎发生中起着重要作用，沿前/后轴沿着指定发育身份。 Ruddle、瓦格纳和Amemiya博士将通过直接测试来确定圆口类和板鳃类等中间形式是否具有中间集群数量，以及在脊索动物进化过程中集群复制是否独立发生一次或多次。 他们还将确定不同的进化枝是否具有不同的Hox基因数量，以及基因的丢失或获得是否相同或不同。 Hox基因组成的差异和相似性将与不同物种的发育状况有关。 他们将详细研究特定的Hox直系同源基因，特别是在比较的基础上检查增强子结构和功能的相似性和差异。 通过这些方法，他们希望更好地理解发育调节和进化过程之间的关系。