Organic Free Radical Chemistry

本研究的重点是自由基动力学和机理的研究。Newcomb博士将开展几个项目，包括直接、激光闪光光解和各种自由基反应的间接动力学测量。一个目标是创建取代碳自由基和杂原子中心自由基的动力学尺度，以补充高度发达的简单烷基自由基的尺度，部分工作是针对特定的重要目标，如DNA自由基反应的动力学。此外，重点将放在超快自由基重排的研究。有了这个更新奖，有机动力学项目支持韦恩州立大学化学系的Martin E. Newcomb博士的研究。纽科姆教授将集中精力研究碳自由基中间体的动力学和力学性质。对这些领域的更好理解将导致合成化学家的方法和知识的扩展，这些方法和知识将与一些重要的生物过程有关。

The focus of this research is radical kinetic and mechanistic studies. Dr. Newcomb will carry out several projects that involve both direct, laser flash photolysis and indirect kinetic measurements of reactions of a variety of radicals. One aim is to create kinetic scales for substituted carbon radicals and heteroatom-centered radicals that complement the highly developed scale for simple alkyl radicals, and part of the work is directed at specific important targets such as the kinetics of DNA radical reactions. In addition, emphasis will be placed on studies of ultrafast radical rearrangements. With this renewal award, the Organic Dynamics Program is supporting the research of Dr. Martin E. Newcomb of the Department of Chemistry at Wayne State University. Professor Newcomb will focus his work on probing the kinetic and mechanistic properties of carbon radical intermediates. A better understanding in these areas will lead to expanded methodology for synthetic chemists and knowledge that will bear on a number of vital biological processes.