U.S.-France Cooperative Research: Studies of Kinetics of Iminyl Radical Cyclizations

这个为期两年的奖项支持韦恩州立大学的Martin Newcomb和巴黎综合理工学院的S. Z. Zard在有机动力学方面的美法合作研究。他们的研究涉及非常快的自由基反应的动力学测量。他们将研究稳定的以碳和氮为中心的自由基，它们是带有奇数电子的中性原子团。韦恩州立大学的研究小组已经开发出一种通用的方法来研究大范围的自由基的动力学。这个法国小组将为韦恩州立大学开发的动力学方法专门设计前体。他们将分离和表征反应产生的产物。然后，韦恩州立大学的研究小组将测量反应的速率常数，并制定一个自由基动力学的尺度。美国研究人员为这次合作带来了物理有机化学方面的专业知识。法国研究人员在有机合成方面的专业知识补充了这一点。他们的共同工作将促进对这种新方法的理解，这种新方法可用于研究涉及自由基中间体的各种有机和生物反应。＊＊＊

9314294 Newcomb This two-year award supports U.S.-France cooperative research in organic dynamics between Martin Newcomb of Wayne State University and S. Z. Zard of the Ecole Polytechnique. Their research involves kinetic measurements of very fast free radical reactions. They will study stabilized carbon-and nitrogen- centered radicals, which are neutral groups of atoms with an odd number of electrons. The Wayne State group has developed a general method for the kinetic study of a broad range of radicals. The French group will prepare precursors specifically designed for the kinetic method developed by Wayne State. They will isolate and characterize products resulting from the reactions. The Wayne State group will then measure the rate constants of the reactions and develop a scale of radical kinetics. The U.S. investigators bring to this collaboration expertise in physical organic chemistry. This is complemented by the French investigators' expertise in organic synthesis. Their joint work will advance understanding of this new method which could be used in studying a wide variety of organic and biological reactions that involve radical intermediates. ***