Early Embryonic Heart Function and the Influence of InternalExternal Environmental Factors on Developmental Trajectories
早期胚胎心脏功能及内外环境因素对发育轨迹的影响
基本信息
- 批准号:9616138
- 负责人:
- 金额:$ 6.9万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:1997
- 资助国家:美国
- 起止时间:1997-08-01 至 1998-09-29
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
9616138 Burggren Our understanding of the forming cardiovascular system of early embryos remains extraordinarily limited for any vertebrate, including mammals. Simply put, the vertebrate embryo remains a "black box" from an "organismal physiology" perspective. Consequently, the major objectives of this proposal are to: 1) investigate the onset of cardiovascular function by determining experimentally the physiological mechanisms leading to flow and pressure generation in early stages of heart development; 2) clearly define and delineate the "critical windows" for cardiovascular development; 3) determine whether "development trajectories" - established early in embryonic development and dictated by genotype - can be diverted through challenge by environmental factors to produce altered embryonic/larval phenotype. Measurements will be made zebrafish, the African clawed frog, and the domestic fowl. The first phase of experiments will include measurements during the early embryonic period of in vivo physiological variables. The second experimental phase will consist of rearing populations of developing embryos under low oxygen and assessing their physiological performance and anatomical development. These studies on early embryonic cardiovascular development and how relevant environmental factors (e.g. hypoxia) impact it will have very broad applicability to both vertebrate physiology and developmental biology, particularly in the almost complete absence of similar published data for vertebrate embryos.
小行星9616138 对于任何脊椎动物,包括哺乳动物,我们对早期胚胎心血管系统形成的理解仍然非常有限。 简而言之,从“生物生理学”的角度来看,脊椎动物胚胎仍然是一个“黑匣子”。 因此,本研究的主要目的是:1)通过实验确定心脏发育早期导致血流和压力产生的生理机制,研究心血管功能的开始; 2)明确定义和描绘心血管发育的“关键窗口”; 3)确定“发育轨迹”--在胚胎发育早期建立并由基因型决定--是否可以通过环境因素的挑战而转向,以产生改变的胚胎/幼虫表型。 将对斑马鱼、非洲爪蛙和家禽进行测量。 第一阶段的实验将包括在早期胚胎期的体内生理变量的测量。 第二个实验阶段将包括在低氧条件下饲养发育中的胚胎群体,并评估其生理表现和解剖发育。 这些关于早期胚胎心血管发育以及相关环境因素(例如缺氧)如何影响它的研究将对脊椎动物生理学和发育生物学具有非常广泛的适用性,特别是在几乎完全缺乏脊椎动物胚胎的类似已发表数据的情况下。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Warren Burggren其他文献
Circulatory changes associated with the closure of the ductus arteriosus in hatching emu (<em>Dromaius novaehollandiae</em>)
- DOI:
10.1016/j.cbpa.2015.11.006 - 发表时间:
2016-01-01 - 期刊:
- 影响因子:
- 作者:
Lauren Shell;Warren Burggren;David Muirhead;Thomas C. Nelson;Edward M. Dzialowski - 通讯作者:
Edward M. Dzialowski
Development and sex affect respiratory responses to temperature and dissolved oxygen in the air-breathing fishes Betta splendens and Trichopodus trichopterus
- DOI:
10.1007/s10695-024-01411-9 - 发表时间:
2024-12-16 - 期刊:
- 影响因子:2.500
- 作者:
My Phuong Le;Warren Burggren;Gil Martinez-Bautista - 通讯作者:
Gil Martinez-Bautista
Warren Burggren的其他文献
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{{ truncateString('Warren Burggren', 18)}}的其他基金
Non-Genetic Inheritance of Hypoxia Tolerance in Fishes: Dynamics and Mechanisms
鱼类耐缺氧性的非遗传性:动力学和机制
- 批准号:
2103499 - 财政年份:2021
- 资助金额:
$ 6.9万 - 项目类别:
Continuing Grant
Epigenetic Inheritance of Physiological Phenotypes: Occurrence, Mechanism and Inter-and Intra-individual Variation
生理表型的表观遗传:发生、机制以及个体间和个体内变异
- 批准号:
1543301 - 财政年份:2015
- 资助金额:
$ 6.9万 - 项目类别:
Continuing Grant
Developmental Co-dependence and Embryonic Programming of Cardiac and Renal Systems Function in Vertebrates - II
脊椎动物心脏和肾脏系统功能的发育相互依赖性和胚胎编程 - II
- 批准号:
1025823 - 财政年份:2010
- 资助金额:
$ 6.9万 - 项目类别:
Continuing Grant
EAGER: Environmental Alterations of the Animal Development Plan: Testing the Heterokairy Hypothesis
EAGER:动物发育计划的环境改变:检验异质凯氏假说
- 批准号:
0942287 - 财政年份:2009
- 资助金额:
$ 6.9万 - 项目类别:
Standard Grant
Development of Cardiovascular Regulatory Mechanisms: Exploring the Early Embryonic Frontier II
心血管调节机制的发展:探索早期胚胎前沿II
- 批准号:
0614815 - 财政年份:2006
- 资助金额:
$ 6.9万 - 项目类别:
Continuing Grant
Embryonic Transitions in Vertebrate Cardiovascular Physiology - II
脊椎动物心血管生理学中的胚胎转变 - II
- 批准号:
0128043 - 财政年份:2002
- 资助金额:
$ 6.9万 - 项目类别:
Continuing Grant
Early Embryonic Heart Function and the Influence of Internal External Environmental Factors on Developmental Trajectories
早期胚胎心脏功能及内外环境因素对发育轨迹的影响
- 批准号:
9896388 - 财政年份:2000
- 资助金额:
$ 6.9万 - 项目类别:
Continuing Grant
CONFERENCE: Travel Support for 5th International Congress of Comparative Physiology and Biochemistry to be held in Calgary, Alberta, Canada from August 23-28, 1999.
会议:为 1999 年 8 月 23 日至 28 日在加拿大艾伯塔省卡尔加里举行的第五届国际比较生理学和生物化学大会提供差旅支持。
- 批准号:
9979751 - 财政年份:1999
- 资助金额:
$ 6.9万 - 项目类别:
Standard Grant
Embryonic Hemodynamics: Ontogeny and Environmental Modifiers
胚胎血流动力学:个体发育和环境调节剂
- 批准号:
9307832 - 财政年份:1993
- 资助金额:
$ 6.9万 - 项目类别:
Continuing Grant
AIT-CCNAA Cooperative Research: Altitudinal Variation in Metabolic Physiology of Brown Frogs, Rana sauteri
AIT-CCNAA 合作研究:褐蛙代谢生理学的海拔变化
- 批准号:
9296095 - 财政年份:1992
- 资助金额:
$ 6.9万 - 项目类别:
Standard Grant
相似海外基金
Maternal Genes that Control Early Embryonic Development as Risk Factors for Congenital Heart Defects
控制早期胚胎发育的母体基因是先天性心脏病的危险因素
- 批准号:
9982092 - 财政年份:2019
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The physiological role of embryonic hemoglobin, the heart rate, and circulation in early vertebrate ontogeny.
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- 批准号:
443698-2013 - 财政年份:2015
- 资助金额:
$ 6.9万 - 项目类别:
Alexander Graham Bell Canada Graduate Scholarships - Doctoral
The physiological role of embryonic hemoglobin, the heart rate, and circulation in early vertebrate ontogeny.
胚胎血红蛋白、心率和循环在早期脊椎动物个体发育中的生理作用。
- 批准号:
443698-2013 - 财政年份:2014
- 资助金额:
$ 6.9万 - 项目类别:
Alexander Graham Bell Canada Graduate Scholarships - Doctoral
The physiological role of embryonic hemoglobin, the heart rate, and circulation in early vertebrate ontogeny.
胚胎血红蛋白、心率和循环在早期脊椎动物个体发育中的生理作用。
- 批准号:
443698-2013 - 财政年份:2013
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$ 6.9万 - 项目类别:
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Investigating the Early Embryonic Murine Heart Using Optical Coherence Tomography
使用光学相干断层扫描研究早期胚胎小鼠心脏
- 批准号:
7908895 - 财政年份:2009
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Investigating the Early Embryonic Murine Heart Using Optical Coherence Tomography
使用光学相干断层扫描研究早期胚胎小鼠心脏
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8099497 - 财政年份:2009
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$ 6.9万 - 项目类别:
Investigating the Early Embryonic Murine Heart Using Optical Coherence Tomography
使用光学相干断层扫描研究早期胚胎小鼠心脏
- 批准号:
7635931 - 财政年份:2009
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Investigating the Early Embryonic Murine Heart Using Optical Coherence Tomography
使用光学相干断层扫描研究早期胚胎小鼠心脏
- 批准号:
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Optical imaging analysis of the functional organization of the receptor-intracellular signal transduction system in the early embryonic heart.
早期胚胎心脏受体细胞内信号转导系统功能组织的光学成像分析。
- 批准号:
16590166 - 财政年份:2004
- 资助金额:
$ 6.9万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Early Embryonic Heart Function and the Influence of Internal External Environmental Factors on Developmental Trajectories
早期胚胎心脏功能及内外环境因素对发育轨迹的影响
- 批准号:
9896388 - 财政年份:2000
- 资助金额:
$ 6.9万 - 项目类别:
Continuing Grant