Exploring Electronic Control in Poly-Reactive Intermediates

探索多反应中间体的电子控制

• 批准号: 9622194
• 负责人: Robert Sheridan
• 金额: $ 29.7万
• 依托单位: Board of Regents, NSHE, obo University of Nevada, Reno
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-04-15 至 2000-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9622194&HistoricalAwards=false
• 关键词: Exploring; Electronic; Control; Poly; Reactive

The focus of this research is to investigate the dynamics of poly-reactive intermediates which are generated intramolecularly within a matrix. The key feature will be the interaction of the biscarbene or carbene-nitrene electrons through anti-ferromagnetic connectors. Possible uses of this investigation include cross-linking polymeric chains, bis-photoaffinity labeling and photoactivated antitumor agents. With this renewal award, the Organic Dynamics Program is supporting the research of Dr. Sheridan of the University of Nevada-Reno. Professor Sheridan will focus on understanding the chemistry of a cluster reactive intermediates. He will generate them with light and study them at low temperatures in isolated matrices. The possible technological applications include photoaffinity labeling and photoactivated antitumor agents.

本研究的重点是研究在分子内生成的多反应中间体的动力学。主要特征将是比斯卡宾或卡宾-亚硝基电子通过反铁磁连接器的相互作用。这项研究的可能用途包括交联聚合链、双光亲和标记和光激活抗肿瘤药物。有了这个更新奖，有机动力学计划支持内华达大学里诺分校的谢里丹博士的研究。谢里丹教授将着重于了解簇反应中间体的化学性质。他将用光产生它们，并在低温下在孤立的基质中研究它们。可能的技术应用包括光亲和标记和光激活抗肿瘤剂。