Exploring Electronic Control in Poly-Reactive Intermediates

这项研究的重点是研究在基质中分子内生成的多反应中间体的动力学。关键特征将是双卡宾或卡宾-硝化电子通过反铁磁连接器的相互作用。这项研究的可能用途包括交联聚合链、双光亲和标记和光活化抗肿瘤药物。有了这一续期奖，有机动力学项目将支持内华达大学雷诺分校谢里丹博士的研究。谢里登教授将专注于了解簇状活性中间体的化学。他将用光产生它们，并在隔离的基质中在低温下研究它们。可能的技术应用包括光亲和标记和光激活抗肿瘤药物。

The focus of this research is to investigate the dynamics of poly-reactive intermediates which are generated intramolecularly within a matrix. The key feature will be the interaction of the biscarbene or carbene-nitrene electrons through anti-ferromagnetic connectors. Possible uses of this investigation include cross-linking polymeric chains, bis-photoaffinity labeling and photoactivated antitumor agents. With this renewal award, the Organic Dynamics Program is supporting the research of Dr. Sheridan of the University of Nevada-Reno. Professor Sheridan will focus on understanding the chemistry of a cluster reactive intermediates. He will generate them with light and study them at low temperatures in isolated matrices. The possible technological applications include photoaffinity labeling and photoactivated antitumor agents.