UV-induced DNA damage in photoaging and skin homeostasis (A07)

光老化和皮肤稳态中紫外线诱导的 DNA 损伤 (A07)

• 批准号: 109199317
• 金额: --
• 依托单位: Institute for Genome Stability in Ageing and Disease
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2009
• 资助国家: 德国
• 起止时间: 2008-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/109199317?language=en
• 关键词: UV; induced; DNA; damage; photoaging

UV-induced DNA lesions promote photoaging and cause skin cancer development. We have established that UV-induced lesions that lead to stalling of the RNAPII complex elicit a response programs that is highly conserved from the nematode C. elegans to mammals. Importantly, the response program augments the maintenance of tissues and thus counteracts the detrimental consequences of DNA damage. We seek understanding of the molecular mechanisms that orchestrate physiological adjustments to the presence of persistent DNA damage.

紫外线诱导的DNA损伤会促进光老化，并导致皮肤癌的发展。我们已经确定，紫外线诱导的损伤导致RNAPII复合体的停滞，引起从线虫到哺乳动物高度保守的反应程序。重要的是，响应程序增加了对组织的维护，从而抵消了DNA损伤的有害后果。我们寻求了解协调生理调节的分子机制，以应对持续性DNA损伤的存在。