New Versatile and Stable Artificial Enzymes

新型多功能且稳定的人工酶

• 批准号: 9625003
• 负责人: T. Randall Lee
• 金额: $ 34.98万
• 依托单位: University of Houston
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-05-01 至 2001-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9625003&HistoricalAwards=false
• 关键词: New; Versatile; Stable; Artificial; Enzymes

With funding from the Organic Dynamics Program, Professor Lee of the University of Houston will investigate new and versatile approaches to the preparation of artificial enzymes. The research will focus on the use of alkanethio units to bind a monolayer of cyclodextrin moieties to a gold surface. Further, within the cyclodextrin cavity, additional alkanethio units shall be bonded to the gold surface and used to position the reactants for enhanced catalytic activity. For the education portion of the investigation, the principal investigator will facilitate student understanding of the industrial environment by inviting several lecturers from the local industries to talk in a new course on `Process Chemistry and Environmental Aspects of Petrochemistry`. In addition, a second course will be added on the subject `Chemistry in Context`. Control of reaction topology to facilitate a desired reaction is the main goal of many scientists. This award from the Organic Dynamics Program addresses this theme by tethering artificial catalytic units to gold surfaces and using alkanethio units to tune the inner catalytic environment. The education portion of the award will focus on preparing undergraduate and graduate students for their post-graduate careers by introducing two new courses. The first course will teach them how chemistry is involved in the everyday life and is titled, `Chemistry in Context`. For the second course, industrial scientists will be invited to give several lectures and perspectives of industrial careers.

在有机动力学项目的资助下， 休斯顿大学将研究新的和多功能的方法， 人工酶的制备。研究将集中在使用 以将环糊精部分的单层结合到 黄金表面此外，在环糊精空腔内，另外的 链烷硫基单元应结合到金表面，并用于定位 用于增强催化活性的反应物。教育部分 在调查过程中，首席研究员将帮助学生 通过邀请几位讲师了解工业环境 在一门新的课程中谈论“过程化学” 石油化学的环境问题。此外，第二 将增加一门关于“环境中的化学”的课程。 控制反应拓扑结构以促进所需反应是本发明的目的。 许多科学家的目标。有机动力学奖 该计划通过将人工催化单元拴系到 金表面，并使用烷硫基单元来调节内催化 环境该奖项的教育部分将侧重于准备 本科生和研究生为他们的研究生职业生涯， 推出两条新路线。第一堂课将教他们如何 化学涉及到日常生活，并被称为“化学在 上下文`。第二个课程将邀请工业科学家， 做了几次讲座和对工业职业的看法。