CAREER: Computer Modeling of Bone

9625030 Keaveny的目标是通过将本科和研究生阶段的研究与教学相结合，在加州大学伯克利分校开发一个全面的骨科生物力学课程。 从拟议的computatinal研究的发展将被纳入现有的生物力学本科班的方式引入一个实验室为基础的计算机项目。 其他教学目标包括：在计算生物力学一个新的研究生课程的发展;为本科生和研究生介绍研究研讨会，以协助职业选择;本科生和研究生在拟议的研究列入;在加州大学伯克利分校和矫形外科在加州大学旧金山分校的机械工程系之间的研究和教学合作的扩展;并为本科生生物力学课程制作实验程序的短视频和基于CD ROM的教科书。 主要的研究目标是开发一个计算框架的生物力学的骨小梁的研究，并使用这个框架来解决一些基本问题，这个复杂的生物组织的力学行为。 这些问题主要涉及组织在微观结构水平上的力学行为与整个试样水平上的力学性能之间的关系。 具体而言，将研究样本内最大应力和应变位置与小梁孔隙率和结构之间的关系，以及伴随这些趋势的失效模式。 还将确定这些趋势对解剖部位、损伤、骨丢失、组织特性变化和加载模式（如拉伸、压缩、剪切、离轴和多轴）的敏感性。 与劳伦斯利弗莫尔国家实验室的研究人员合作，将开发对多达1亿个元素的模型进行大规模并行计算的能力，以执行40个松质骨标本的三维“高分辨率”有限元模型。 将根据从一系列解剖部位采集的另外40个松质骨样本的实验数据对建模技术进行前瞻性验证。 然后将进行有限元参数研究，以解决特定的研究目标。 本计画的结果将与骨小梁的生物形态与功能关系、老化、疾病、创伤、药物开发、人工骨替代物等相关。 计算的发展也将提高对任何几何复杂结构进行应力分析的能力，甚至超出生物工程领域。 ***

9625030 Keaveny The goal is to develop a comprehensive program in orthopaedic biomechanics at UC Berkeley by integrating research with teaching at both the undergraduate and graduate levels. Developments from the proposed computatinal research will be incorporated into an existing undergraduate class in biomechanics by way of introducing a laboratory-based computer project. Other teaching objectives include: development of a new graduate course in computational biomechanics; introduction of research seminars for undergraduates and graduates to assist in career choices; inclusion of undergraduates and graduates in the proposed research; expansion of research and teaching collaboration between the Departments of Mechanical Engineering at UC Berkeley and Orthopaedic Surgery at UCSF; and development of short videos of experimental procedures and a CD ROM-based textbook for the undergraduate biomechanics class. The major research goal is to develop a computational framework for the study of the biomechanics of trabecular bone and to use this framework to address a number of fundamental issues on the mechanical behavior of this complex biological tissue. These issues are concerned primarily with the relationships between the mechanical behavior of tissue at the microstructural level vs. the mechanical properties at the whole specimen level. Specifically, relationships between locations of maximum stress and strain within the specimen vs. trabecular porosity and architecture will be investigated as well as the failure modes that accompany these trends. The sensitivity of these trends to anatomic site, damage, bone loss, variations in tissue properties, and loading modes such as tension, compression, shear, off-axis, and multi- axis will also be determined. In collaboration with researchers from Lawrence Livermore National Laboratory, capabilities will be developed to perform three- dimensional "high-resolution" finite element models of 40 trabecular bone spe cimens, using massively parallel computation on models with up to 100 million elements. The modeling technique will be prospectively validated against experimental data for an additional 40 specimens of trabecular bone taken from a range of anatomic sites. Finite element parameter studies will then be performed to address the specific research objectives. Results from this project will be relevant to biological form-function relations in trabecular bone, aging, diseasae, trauma, drug development, and artificial bone substitutes. The computational developments will also improve the ability to perform stress analyses on any geometrically complex structure, even beyond the realm of bioengineering. ***