Proposal to Upgrade the UC Berkeley College of Chemistry NMR Facility

该奖项由化学研究仪器和设施 （CRIF）计划将协助大学化学系 加州伯克利分校的教授获得了核磁共振。 该设备将增强 研究领域包括：（1）应用 有机合成的生物学问题，包括螺旋成核剂， 大环肽酶抑制剂（2）合成与探索化学 有机金属化合物及其反应的研究 机理（3）有机合成方法学与全合成 天然产物，包括萨拉戈萨酸和dictyoxetane（4） 生物系统中的分子识别和催化作用， 这些研究的应用，以设计和合成新的 具有新的生物学特性的分子，和（5）探索性的 新型无机体系的合成、结构和反应性研究 包括过渡金属-硅化学和金属介导的途径， 电荷传输聚合物。 核磁共振（NMR）光谱是最强大的工具， 化学家用来阐明分子结构的仪器。 它用于识别未知物质，表征特定物质， 分子内原子的排列，并研究 溶液中分子间的相互作用获得最新技术 核磁共振谱是化学家进行前沿研究的基础 research.这些NMR研究的结果在以下领域是有用的， 聚合物，催化剂，以及生物学

This award from the Chemistry Research Instrumentation and Facilities (CRIF) Program will assist the Department of Chemistry at the University of California Berkeley acquire a NMR. This equipment will enhance research in a number of areas including the following: (1) application of organic synthesis to biologial problems including helix nucleators and macrocyclic peptidase inhibitors (2) synthesis and exploratory chemistry of organometallic compounds and the investigations of their reaction mechanisms (3) organic synthesis methodology and total synthesis of natural products including zaragozic acid and dictyoxetane (4) molecular recognition and catalysis in biological systems and applications of these studies to the design and synthesis of new molecules with novel biological properties, and (5) exploratory synthetic, structural and reactivity studies on novel inorganic systems including transition metal-silicon chemistry and metal-mediated routes to charge-transporting polymers. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometry is essential to chemists who are carrying out frontier research. The results from these NMR studies are useful in the areas such as polymers, catalysis, and in biology