Real-Time Processing and Multi-Spectral Imaging Equipment for Intraocular Image Processing

这项研究涉及两个组成部分。 第一个组成部分是在NSF资助MIP-9412500下的先前工作的扩展，该工作是关于开发用于自动生成视网膜脉管系统图的算法，以及基于实时特征的从眼内数字视频图像序列确定视网膜位置。 具体地说，将使用TMS 320 C80视频信号处理器芯片，通过将建立跟踪锁定所需的时间减少到少量视频帧间隔来实现完全透明的图像跟踪。 这项研究的第二个组成部分是修改眼底成像系统下获得的前一个奖项，以实现同时成像在近红外和可见光波段使用一对低光摄像机。 该仪器将用于研究在晚期吲哚菁绿色血管造影片上人工叠加计算血管标志的实时算法。 这项研究将导致实时图像处理硬件和软件技术的发展，使激光视网膜手术和相关应用的新仪器的发展。 其动机是需要降低目前程序的高失败率（接近50%）。 该项目是高性能计算技术的应用，使眼科学和生物学和医学的相关问题的新进展。 除了降低失败率外，这项技术还有望通过消除重复矫正手术的需要来降低激光视网膜手术的成本。

This research involves two components. The first component is an extension of prior work under NSF grant MIP-9412500 on the development of algorithms for automatic generation of retinal vasculature maps, and real-time feature-based determination of retinal position from intra-ocular digital video image sequences. Specifically, a TMS320C80 video signal processor chip will be used to achieve fully transparent image tracking by reducing the time required to establish a tracking lock to a small number of video frame intervals. The second component to this research is to modify the fundus imaging system acquired under the previous award to achieve simultaneous imaging in the near infrared and visible bands using a pair of low-light video cameras. This instrumentation will be used to investigate real-time algorithms for artificially superimposing computed vasculature landmarks on late-phase Indocyanine Green angiograms. This research will result in the development of real-time image processing hardware and software technology for enabling the development of novel instrumentation for laser retinal surgery and related applications. It is motivated by the need to reduce the currently high failure rate (approaching 50%) of current procedures. This project is an application of high-performance computing technology to enable new advances in ophthalmology and related problems in biology and medicine. In addition to reducing the failure rate, this technology is expected to reduce the cost of laser retinal surgery by eliminating the need for repeated corrective procedures.