CAREER: Metal-Mediated Formation and Cleavage of Phosphorus-Carbon Bonds

职业：金属介导的磷碳键的形成和断裂

• 批准号: 9701860
• 负责人: David Glueck
• 金额: $ 35.2万
• 依托单位: Dartmouth College
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-05-01 至 2002-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9701860&HistoricalAwards=false
• 关键词: CAREER; Metal; Mediated; Formation; Cleavage

This CAREER Award in the Inorganic, Bioinorganic and Organometallic Chemistry Program supports the research and education plans of David S. Glueck of Dartmouth College. The goal of the proposed research is to understand the formation of phosphorous-carbon (P-C) bonds to develop metal-catalyzed syntheses of chiral phosphines and to design phosphine ligands resistant to P-C bond cleavage. Mechanistic studies of reductive elimination and oxidative addition reactions with organophosphorous species will guide chiral catalyst development and test the hypothesis that arylphosphines with electron-donating substitutents will resist degradation. A new course will be developed to improve the scientific literacy of liberal arts students by taking an interdisciplinary look at a few top industrial chemicals. The industrial chemistry, economics, and environmental impacts of these chemicals will be explored.

这个无机化学、生物无机化学和金属有机化学项目的职业奖支持达特茅斯学院的大卫·S·格鲁克的研究和教育计划。这项研究的目的是了解磷-碳键的形成，以开发金属催化的手性膦的合成，并设计抗磷-碳键断裂的膦配体。有机磷物种的还原消除和氧化加成反应的机理研究将指导手性催化剂的开发，并验证带有给电子取代基的芳基膦将抵抗降解的假说。将开发一门新课程，通过跨学科研究几种顶级工业化学品来提高文科学生的科学素养。本课程将探讨这些化学品的工业化学、经济和环境影响。