Metal Mediated and Catalyzed Organic Synthetic Methods

金属介导和催化的有机合成方法

• 批准号: RGPIN-2022-04761
• 负责人: Green, James
• 金额: $ 1.75万
• 依托单位: University of Windsor
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=748461
• 关键词: Metal; Mediated; Catalyzed; Organic; Synthetic

The purpose of this proposal is the development and application of new organic chemistry synthetic methods, based on organic reactions mediated by transition metal species. The projects proposed in this grant build upon the developments of our previous Discovery Grant and yet investigate new directions. Central to the individual methods under study is the ability of the transition metal unit to make possible transformations either difficult or impossible by normal synthetic methods, by either stabilizing intermediates or by stabilizing products that could not exist in the absence of the transition metal unit, with particular focus on the alkyne-Co2(CO)6 unit. The specific processes focused on will come from the ability of this unit to stabilize positively charged (carbocation) species, and the ability to make triple bond species in ring containing compounds stable. In addition, we intend to study the effects of the alkyne-Co2(CO)6 unit on intermediates with unpaired electrons (radicals), and whether these intermediates are made more useful in synthesis by the presence of the cobalt unit. The underlying mechanistic aspects of the chemistry under study will also be explored. It is ultimately intended that the chemistry will developed to the point where the parameters of the chemistry is well understood, and the  the synthesis of selected target compounds will be undertaken, to demonstrate to utility of the method and to make naturally occurring compounds that have seen little attention in terms of synthesis.

该提案的目的是开发和应用基于过渡金属物种介导的有机反应的新的有机化学合成方法。在这个补助金提出的项目建立在我们以前的发现补助金的发展，但调查新的方向。所研究的各个方法的核心是过渡金属单元通过稳定中间体或稳定在没有过渡金属单元的情况下不可能存在的产物，特别关注炔-Co 2（CO）6单元，使可能的转化通过正常合成方法变得困难或不可能的能力。重点关注的具体过程将来自该单元稳定带正电荷（碳阳离子）物质的能力，以及使含环化合物中的三键物质稳定的能力。此外，我们打算研究的影响的炔-钴2（CO）6单元上的中间体与不成对电子（自由基），以及是否这些中间体是更有用的合成钴单元的存在下。还将探讨正在研究的化学的基本机制方面。最终目的是将化学发展到化学参数被很好地理解的程度，并且将进行所选目标化合物的合成，以证明该方法的实用性并制备在合成方面很少受到关注的天然存在的化合物。