CAREER: New Methods of Creating Artifical Receptors for Proteins

Mallik教授的研究重点是设计，合成和 用于蛋白质表面的基于脂质体的受体的评价。 混合 衍生自含金属脂质的可聚合离子脂质体 脂质和可聚合的氢键合脂质平衡， 模板蛋白碳酸酐酶来创建三维的， 蛋白质表面的互补复制品。 合成目标包括 含有不同头基和可光聚合的二烯的脂质，或 二炔尾，在平衡后，光化学聚合， 获得半刚性的蛋白质特异性受体。疗效 光聚合模板合成通过测量 蛋白质复制结合常数。 教育活动的主要障碍有 介绍研究生生物有机课程，并解决本科生 通过在网上建立虚拟有机化学教室， 促进师生沟通。 有了这个职业奖，有机动力学计划支持 Sanku Mallik教授的研究和教育活动 北达科他州大学化学系。 教授 马利克的研究重点是创造一个三维的 蛋白质识别表面，通过使用特定的蛋白质来引导蛋白质识别表面的蛋白质。 与之相互作用的分子集合的形成。 随后这些分子有效地化学连接成聚合物 在所得聚合物中留下蛋白质的足迹。 相比之下 其他方法所涉及的相当大的综合努力， 分子识别，这种方法预计将产生简单， 快速形成靶蛋白的高度特异性结合位点。 马利克教授的教育活动包括培养一名毕业生 以有机和生物之间的界面为目标的课程 化学及促进师生沟通， 网上的虚拟教室

Professor Mallik's research focuses on the design, synthesis and evaluation of liposome based receptors for protein surfaces. Mixed liposomes derived from metal containing lipids, polymerizable ionic lipids, and polymerizable hydrogen bonding lipids are equilibrated with the template protein carbonic anhydrase to create a three-dimensional, complementary replica of the protein surface. Synthetic targets include lipids containing differing head groups and photopolymerizable diene or diyne tails that, after equilibration, are photochemically polymerized to achieve a semi-rigid, protein-specific receptor. Efficacy of the photopolymerized template synthesis is quantified by measuring the protein-replica binding constants. Educational activities include introducing a graduate bio-organic course and addressing undergraduate needs by establishing a Virtual Organic Chemistry classroom on the Web to facilitate student-teacher communication. With this CAREER award, the Organic Dynamics Program supports the research and educational activities of Professor Sanku Mallik of the Department of Chemistry at the University of North Dakota. Professor Mallik's research is focused on the creation of a three-dimensional protein recognition surface by using a specific protein to direct the formation of a collection of molecules with which it interacts. Subsequent chemical linking of these molecules into a polymer effectively leaves a footprint of the protein in the resulting polymer. In contrast to the considerable synthetic effort involved in other approaches to molecular recognition, this approach is expected to generate simply and rapidly a highly specific binding site for the target protein. Professor Mallik's educational activities include developing a graduate curriculum targeting the interface between organic and biological chemistry and facilitating student-teacher communication through a Virtual Classroom on the Web.