Arkansas Center for Membrane Biology
阿肯色州膜生物学中心
基本信息
- 批准号:9704712
- 负责人:
- 金额:$ 58.87万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:1997
- 资助国家:美国
- 起止时间:1997-06-01 至 2000-05-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
9704712 Jennings The objective of the proposed project is to develop the Arkansas Center for Membrane Biology at the University of Arkansas for Medical Sciences (UAMS). The rationale for choosing membrane biology for development is that expertise in the study of membrane receptors, transporters, and channels will complement and augment several existing basic research strengths at UAMS, including neuroscience, glycobiology, endocrinology, virology, and toxicology. The Chancellor and the Dean of the College of Medicine at UAMS have made a major commitment to building in this area with the hiring in 1995 of the P.I. of this proposal, Michael L. Jennings, as Chairman of the Department of Physiology and Biophysics. Newly renovated laboratory space and salary lines to hire six faculty (three new positions and three replacements) have been provided to Dr. Jennings. Two additional faculty recently hired with adjunct appointments in Physiology and Biophysics will also contribute importantly to the critical mass of investigators in membrane biology. NSF EPSCoR funds are requested to enhance the equipment startup packages for new faculty and to support core facilities that are needed for competitive research in membrane biology. Development of the Center will focus on two themes. The first is the regulation of function of membrane receptors for hormones and neurotransmitters. There are currently four members of this group, with one established investigator, Lawrence E. Comett. The others are George T. Blevins, Jr., Richard C. Kurten, and Dana Gaddy-Kurten, all of whom study different aspects of peptide hormone receptors. Dr. Blevins has been Assistant Professor for three years; Drs. Kuden and Gaddy-Kurten were hired as Assistant Professors in August, 1996. Two additional faculty will be hired in this area. The other group of investigators will use biophysical approaches to study membrane transport and electrophysiology. The nucleus of this group consists of M.L. Jennings, Gerald Dienel, and Z. Jimmy Zhou. Dr. Dienel was hired as Associate Professor in April, 1996, and Dr. Zhou was hired as Assistant Professor in August, 1996. Two additional faculty will be hired in the area of transport biophysics and electrophysiology. The two areas of focus (receptors and biophysics) will not be isolated from each other; there will be constant interaction between the groups, and the faculty to be hired will very likely have interests that overlap both groups. EPSCoR funds are requested for the purchase of equipment and the support of core facilities that will enhance the competitiveness of the target faculty: Blevins, Kuden, Gaddy-Kurten, Dienel, Zhou, and four faculty to be hired. The core facilities are a molecular biology laboratory, a transgenic mouse facility, and computer facility for access to DNA sequence data bases. Funds are also requested for an extensive extramural seminar program, which will allow faculty to interact closely with leading experts in membrane biology. Other funds will be used for summer salary for visiting faculty from neighboring undergraduate institutions and for stipends for graduate students and postdoctoral fellows. Three major equipment items are requested. The first is a work station for the laser manipulation of cells (laser scissors and tweezers), to be used by Drs. Kurten and Gaddy-Kurten to enable them to select rare cells from a population and to do a variety of other cellular manipulations. The second item is equipment for optical imaging of calcium, to be used by Drs. Zhou and Blevins to quantify the time course and spatial pattern of calcium release from intracellular stores or entry across the plasma membrane. The third item is a brain imaging system to be used by Dr. Dienel and several collaborators for analysis of transport and metabolism in intact central nervous system. Additional equipment funds are requested to enhance the startup packages for the four additional faculty to be hired. A plan is in place for the professional development of the faculty in the Center, including the provision of protected time for junior faculty, publication goals, and assistance in preparing grant proposals. The national reputations of faculty will be developed by participation in national meetings and other off campus learning experiences; hosting visits by seminar speakers; presentation of seminars at other institutions; and participation as peer reviewers of manuscripts and grants. The goals over the next few years are for individual faculty to become established investigators with extramural funding, and for major multi-investigator grants to result from common interests and complementary expertise among members of the Center.
拟议项目的目标是发展阿肯色大学医学科学(UAMS)的阿肯色膜生物学中心。选择发展膜生物学的基本原理是,在膜受体、转运体和通道研究方面的专业知识将补充和增强UAMS现有的几个基础研究优势,包括神经科学、糖生物学、内分泌学、病毒学和毒理学。校长和医学院院长在1995年聘请了该提案的pi Michael L. Jennings作为生理和生物物理系的主席,对这一领域的建设做出了重大承诺。新装修的实验室空间和雇用六名教员(三个新职位和三个替代职位)的工资线已经提供给詹宁斯博士。另外两名最近在生理学和生物物理学方面兼职的教员也将为膜生物学研究人员的临界质量做出重要贡献。NSF EPSCoR基金被要求加强新教员的设备启动包,并支持膜生物学竞争性研究所需的核心设施。中心的建设将围绕两个主题展开。首先是调节膜受体对激素和神经递质的功能。目前这个小组有四名成员,其中有一名资深调查员劳伦斯·e·科米特(Lawrence E. Comett)。其他三位分别是George T. Blevins, Jr., Richard C. Kurten和Dana Gaddy-Kurten,他们都研究肽激素受体的不同方面。布莱文斯博士担任助理教授已有三年;Drs。库登和Gaddy-Kurten于1996年8月被聘为助理教授。这一领域将再雇用两名教员。另一组研究人员将使用生物物理方法来研究膜运输和电生理学。这群人的核心包括M.L. Jennings, Gerald Dienel和Z. Jimmy Zhou。Dienel博士于1996年4月被聘为副教授,Zhou博士于1996年8月被聘为助理教授。另外两名教员将在运输生物物理学和电生理学领域被雇用。这两个重点领域(受体和生物物理学)不会彼此孤立;这两个小组之间会有持续的互动,而将要聘用的教员很可能会有与两个小组重叠的兴趣。EPSCoR基金被要求用于购买设备和核心设施的支持,以提高目标教师的竞争力:布莱文斯,库登,Gaddy-Kurten, Dienel,周和四名即将聘用的教师。核心设施是一个分子生物学实验室,一个转基因小鼠设施,以及访问DNA序列数据库的计算机设施。此外,还要求为一个广泛的校外研讨会项目提供资金,这将使教师能够与膜生物学领域的顶尖专家密切互动。其他资金将用于邻近本科院校访问教师的夏季工资,以及研究生和博士后的津贴。需要三个主要设备项目。第一个是用于激光操作细胞的工作站(激光剪刀和激光镊子),供博士使用。和Gaddy-Kurten,使他们能够从群体中选择稀有细胞并进行各种其他细胞操作。第二个项目是钙的光学成像设备,供博士们使用。Zhou和Blevins对钙从细胞内储存或通过质膜释放的时间过程和空间模式进行了量化。第三个项目是一个脑成像系统,供Dienel博士和几位合作者用于分析完整中枢神经系统的运输和代谢。要求提供额外的设备资金,以加强将雇用的另外四名教员的启动包。本中心为教师的专业发展制定了一个计划,包括为初级教师提供受保护的时间,出版目标,并协助准备拨款提案。教师的全国声誉将通过参加全国会议和其他校外学习经验来发展;主办研讨会讲者的访问;在其他机构举办研讨会;以及作为手稿和拨款的同行审稿人参与。未来几年的目标是让个别教员在校外资助下成为成熟的研究人员,并通过中心成员之间的共同兴趣和互补的专业知识获得主要的多研究员资助。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Michael Jennings其他文献
Mathematics and the pharmacokinetics of alcohol
数学和酒精的药代动力学
- DOI:
10.1007/978-94-007-6540-5_51 - 发表时间:
2013 - 期刊:
- 影响因子:0
- 作者:
Michael Jennings;Peter Adams - 通讯作者:
Peter Adams
V11-12 ROBOTIC ADRENALECTOMY FOR METASTATIC MELANOMA
- DOI:
10.1016/j.juro.2016.02.1829 - 发表时间:
2016-04-01 - 期刊:
- 影响因子:
- 作者:
Michael Jennings;Wesley White - 通讯作者:
Wesley White
Totally Geodesic Seifert Surfaces in Hyperbolic Knot and Link Complements I
双曲结和链接补集 I 中的全测地线 Seifert 曲面
- DOI:
10.4310/jdg/1207834655 - 发表时间:
2004 - 期刊:
- 影响因子:0.5
- 作者:
C. Adams;H. Bennett;Christopher Davis;Michael Jennings;Jennifer Novak;Nicholas Perry;E. Schoenfeld - 通讯作者:
E. Schoenfeld
PD45-04 NON-INDUSTRY SPONSORED SAFETY ANALYSIS FOLLOWING COLLAGENASE CLOSTRIDIUM HISTOLYTICUM (XIAFLEX®) INJECTION IN MEN WITH PEYRONIE’S DISEASE
- DOI:
10.1016/j.juro.2016.02.2104 - 发表时间:
2016-04-01 - 期刊:
- 影响因子:
- 作者:
Ryan Owen;Chris Winter;Michael Jennings;Jonathan Angelle;Wesley White;LeRoy Jones;Edward Kim - 通讯作者:
Edward Kim
Large-scale purification of myeloperoxidase from HL60 promyelocytic cells: characterization and comparison to human neutrophil myeloperoxidase.
从 HL60 早幼粒细胞中大规模纯化髓过氧化物酶:表征以及与人中性粒细胞髓过氧化物酶的比较。
- DOI:
- 发表时间:
2000 - 期刊:
- 影响因子:1.6
- 作者:
Heidi Rath Hope;E. Remsen;Charles Lewis;D. Heuvelman;Mark C. Walker;Michael Jennings;Daniel T. Connolly - 通讯作者:
Daniel T. Connolly
Michael Jennings的其他文献
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{{ truncateString('Michael Jennings', 18)}}的其他基金
CAREER: Novel diastereoselective bond forming reactions via siliconate intermediates
职业:通过硅酸酯中间体进行新型非对映选择性成键反应
- 批准号:
0845011 - 财政年份:2009
- 资助金额:
$ 58.87万 - 项目类别:
Continuing Grant
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- 批准号:10974251
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