IUCRC Phase III The Pennsylvania State University: Center for Membrane Applications, Science and Technology (MAST)

膜用于各种工业，例如药物制造、食品和饮料生产、饮用水和废水处理以及从废物流中回收有价值的化学物质。膜应用、科学和技术中心（MAST）正在与这些领域和其他领域的膜制造商和用户合作，以促进科学知识和开发促进人类健康、繁荣和福利的新产品。通过与来自一系列行业的科学家以及四个机构的大学研究人员建立多学科项目团队，MAST中心正在解决具有挑战性的真实的世界技术问题，这些问题在医疗保健和环境可持续性领域具有重大的社会影响。宾夕法尼亚州立大学的工厂特别关注用于生产单克隆抗体、疫苗和基因疗法的膜，以解决这些拯救生命的治疗药物生产中的关键挑战。此外，该研究将利用宾夕法尼亚州立大学在最先进的材料表征仪器方面的重大投资，为学生培训，教育和膜科学技术研究提供独特的环境。膜应用科学技术中心（MAST）在六个领域进行工业相关研究：（1）新膜的开发和表征（2）绿色膜制造方法的开发;（3）开发用于水处理的膜工艺，（4）制造用于（4）生物制药工业的产品，（5）制药工业和（6）食品和饮料工业中的膜应用。该中心与代表膜用户和制造商的工业合作伙伴以及来自四个机构的教师和学生合作，以开发具有挑战性的分离技术解决方案。同时，该中心培养学生成为技术发展的未来领导者。宾夕法尼亚州立大学的工厂特别关注用于生产单克隆抗体、疫苗和基因疗法的膜，利用宾夕法尼亚州立大学在最先进的材料表征仪器方面的重大投资。感兴趣的具体项目包括开发用于腺相关病毒浓缩和纯化的单程切向流过滤，使用电子断层扫描研究由于膜污染引起的孔结构变化，和连续生物处理的高性能逆流膜纯化设计。该奖项反映了NSF的法定使命，并通过使用基金会的学术价值和更广泛的影响审查标准。

Membranes are used in a variety of industries such as the manufacture of drugs, production of food and beverages, treatment of drinking and wastewater and recovery of valuable chemical species from waste streams. The Center for Membrane Applications, Science and Technology (MAST) is collaborating with membrane manufacturers and users in these fields and others, to promote scientific knowledge and to develop new products that advance human health, prosperity and welfare. By establishing multidisciplinary project teams with scientists from a range of industries as well as university researchers across four institutions, the MAST Center is addressing challenging real world technical issues that are of significant societal impact in the areas of healthcare and environmental sustainability. The Penn State site has a specific focus on membranes for the production of monoclonal antibodies, vaccines, and gene therapies, addressing critical challenges in the manufacture of these life-saving therapeutics. In addition, the research will leverage Penn State’s significant investment in state-of-the-art instrumentation for materials characterization, providing a unique environment for student training, education, and research in membrane science and technology. The Center for Membrane Applications, Science and Technology (MAST) conducts industrially relevant research in six areas: (1) development and characterization of new membranes (2) development of green membrane manufacturing methods; (3) development of membrane processes for water treatment, (4) manufacture of products for the (4) biopharmaceutical industry, (5) pharmaceutical industry and (6) membrane applications in food and beverage industries. The Center works with industrial partners representing membrane users and manufacturers and faculty and students from four institutions in order to develop technological solutions to challenging separations. In parallel, the Center trains students to be future leaders of technology development. The Penn State site has a specific focus on membranes for the production of monoclonal antibodies, vaccines, and gene therapies, leveraging Penn State’s significant investment in state-of-the-art instrumentation for materials characterization. Specific projects of interest include the development of single pass tangential flow filtration for the concentration and purification of adeno-associated virus, the use of electron tomography to study changes in pore structure due to membrane fouling, and the design of high performance countercurrent membrane purification for continuous bioprocessing.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.