Polymer/Mucin Adhesion for Targetted Therapy

用于靶向治疗的聚合物/粘蛋白粘附

• 批准号: 9706538
• 负责人: Nicholas Peppas
• 金额: $ 36万
• 依托单位: Purdue Research Foundation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-15 至 2001-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9706538&HistoricalAwards=false
• 关键词: Polymer; Mucin; Adhesion; Targetted; Therapy

9706538 Peppas The goal of this research is the development of improved bioadhesiare and mucoadhesive polymers that can be used for wound healing or as carriers for drug targeting to specific sites of the body. The effect of crosslinking, polymer hydrophilicity, and interdiffusion on the adhesion and cohesion of hydrogels with adhesive functional groups in contact with mucin will be investigated. Hydrogels will be prepared by free radical polymerization of acrylic acid, 2- hydroxy ethyl methacrylate and ethylene glycol dimethacrylate. The surface chemistry of selected polymers will be modified by grafting poly (ethylene glycol) of varying molecular weights. The surface and bulk properties will be characterized by contact angle measurements, gas chromatography, gel permeation chromatography, differential scanning calorimetry and Fourier-transform infrared (FTIR) spectroscopy. Near-field FTIR will be used to study the interdiffusion and adhesion process in contact with mucin and identify the molecular characteristics that will provide maximum mucoadhesion. ***

9706538 Peppas 这项研究的目标是开发改进的生物粘附和粘膜粘附聚合物，可用于伤口愈合或作为药物靶向身体特定部位的载体。 将研究交联、聚合物亲水性和相互扩散对与粘蛋白接触的具有粘合官能团的水凝胶的粘合和内聚力的影响。 水凝胶将通过丙烯酸、甲基丙烯酸2-羟乙酯和二甲基丙烯酸乙二醇酯的自由基聚合来制备。 所选聚合物的表面化学性质将通过接枝不同分子量的聚乙二醇进行改性。 表面和整体特性将通过接触角测量、气相色谱、凝胶渗透色谱、差示扫描量热法和傅里叶变换红外（FTIR）光谱来表征。 近场 FTIR 将用于研究与粘蛋白接触的相互扩散和粘附过程，并确定可提供最大粘膜粘附力的分子特征。 ***