Polymer/Mucin Adhesion for Targetted Therapy

这项研究的目标是开发改进的生物黏合剂和黏合剂聚合物，可用于伤口愈合或作为药物靶向到身体特定部位的载体。研究了交联、聚合物亲水性和相互扩散对粘蛋白接触的具有粘附官能团的水凝胶的粘附和内聚的影响。将丙烯酸、2-羟基甲基丙烯酸乙酯和乙二醇二甲基丙烯酸酯通过自由基聚合制备水凝胶。所选聚合物的表面化学性质将通过接枝不同分子量的聚乙二醇进行修饰。通过接触角测量、气相色谱法、凝胶渗透色谱法、差示扫描量热法和傅里叶变换红外（FTIR）光谱来表征其表面和体性质。近场FTIR将用于研究与粘蛋白接触的相互扩散和粘附过程，并确定能够提供最大黏附的分子特征。＊＊＊

9706538 Peppas The goal of this research is the development of improved bioadhesiare and mucoadhesive polymers that can be used for wound healing or as carriers for drug targeting to specific sites of the body. The effect of crosslinking, polymer hydrophilicity, and interdiffusion on the adhesion and cohesion of hydrogels with adhesive functional groups in contact with mucin will be investigated. Hydrogels will be prepared by free radical polymerization of acrylic acid, 2- hydroxy ethyl methacrylate and ethylene glycol dimethacrylate. The surface chemistry of selected polymers will be modified by grafting poly (ethylene glycol) of varying molecular weights. The surface and bulk properties will be characterized by contact angle measurements, gas chromatography, gel permeation chromatography, differential scanning calorimetry and Fourier-transform infrared (FTIR) spectroscopy. Near-field FTIR will be used to study the interdiffusion and adhesion process in contact with mucin and identify the molecular characteristics that will provide maximum mucoadhesion. ***