Development of nanoscale hydrogels for oral delivery of siRNA

1033746 peppas本提案的目的是合成多阳离子纳米级水凝胶，能够将小干扰RNA （siRNA）递送到疾病靶点，特别是胃肠道靶点。该研究计划描述了一系列变量的表征和优化，这些变量将最终影响水凝胶的适用性。使用ph反应性纳米凝胶载体口服siRNA有望改善各种胃肠道疾病的治疗，因为口服给药比静脉注射和腹腔注射更有效，更少痛苦。申请人管理着一个由40%女性和20%少数族裔学生组成的实验室。作为面向K-12学生的拓展计划的一部分，申请者将为10名高中生提供暑期实习机会。

1033746PeppasThe objective of this proposal is to synthesize polycationic nanoscale hydrogels capable of delivery of small interfering RNA (siRNA) to disease targets, specifically those along the gastrointestinal tract. The research plan describes the characterization and optimization of a number of variables that will ultimately affect the suitability of the hydrogel Oral delivery of siRNA using pH-responsive nanogel carriers promises to improve the treatment of various gastrointestinal diseases because oral delivery is more efficient and less painful than intravenous and intraperitonealI injections. The applicant manages a lab that has 40 % women and 20 % minority students. As part of the outreach to K-12 students, the applicant is offering 10 high school students summer internships.