Dissertation Research: Gross Morphology and Bone Density Patterns in the Knees of Catarrhine Primates with Differing Locomotor Behaviors

论文研究：具有不同运动行为的卡他灵灵长类动物膝盖的大体形态和骨密度模式

• 批准号: 9706991
• 负责人: Jack Stern
• 金额: $ 1.17万
• 依托单位: SUNY at Stony Brook
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-01 至 1999-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9706991&HistoricalAwards=false
• 关键词: Dissertation; Research; Gross; Morphology; Bone

This project examines differences in the bone density patterns at the knee joint in monkeys, apes, and humans with the goal of correlating such differences with locomotion and hindlimb anatomy. It is predicted that primates living in different habitats (trees-dwelling vs. ground-dwelling), or adapted to different locomotor modes (e.g., four-legged vs. two-legged), will subject their knees to different loading patterns. It has been previously determined that patterns of bone density on a joint surface, based on grey scale patterns in CT scans, are correlated with patterns of loading at that joint. This technique will be used to create bone density contour maps of the upper portion of the tibia (shin bone) in an attempt to gain insight into different loading patterns of the primate knee. Once correlations between locomotor behavior, knee anatomy, and CT density patterns are discovered, they will enable the reconstruction of extinct locomotor behaviors. By examining humans and their closest relatives, this research can also benefit studies on the origin of modern pathologies of the human knee and their potential corrections. Lastly, the methods used here can be adapted for conducting similar studies on a variety of joint surfaces in the primate skeleton, thereby expanding our knowledge of the effects of locomotion on the force distribution in joints.

本项目研究猴子、猿和人类膝关节骨密度模式的差异，目的是将这种差异与运动和后肢解剖学联系起来。 据预测，灵长类动物生活在不同的栖息地（树上居住与地面居住），或适应不同的运动模式（例如，四条腿与两条腿），将使他们的膝盖承受不同的负荷模式。 先前已经确定，基于CT扫描中的灰度图案，关节表面上的骨密度图案与该关节处的载荷图案相关。 该技术将用于创建胫骨上部（胫骨）的骨密度等高线图，以尝试深入了解灵长类动物膝关节的不同载荷模式。 一旦发现运动行为、膝关节解剖结构和CT密度模式之间的相关性，它们将能够重建灭绝的运动行为。通过研究人类及其近亲，这项研究也有助于研究人类膝关节的现代病理学起源及其潜在的矫正。最后，这里使用的方法可以适用于进行类似的研究，在灵长类动物骨骼的各种关节表面，从而扩大我们的知识的运动对关节的力分布的影响。