Molecular Genetic Analysis of Life Span Variation in Drosophila melanogaster

9707706服务这个项目的目标是识别控制果蝇衰老的基因。果蝇是一种“模型”生物，多年来一直被用来研究基本的遗传问题。这项研究中使用的苍蝇来自由于实验室中的选择性繁殖而导致平均寿命相差两倍以上的种群。这种寿命上的差异是由于衰老速度的不同。衰老速度越快的苍蝇寿命越短。该项目将提供关于导致这些苍蝇种群之间寿命和衰老差异的基因数量的数据。它还将使识别这些基因的大致染色体位置成为可能。这个项目将有助于我们理解衰老的分子和遗传学基础。由于所有动物在分子和细胞水平上有许多基本相似之处，该项目可能会提供广泛适用于包括人类在内的许多经历衰老和衰老的动物物种的结果。

9707706 Service The goal of this project is to identify genes that control senescence in the fruit fly, Drosophila melanogaster. The fruit fly is a "model" organism that has been used for many years to investigate fundamental genetic questions. The flies to be used in this study are from populations that have a more than two-fold difference in average life span as a result of selective breeding in the laboratory. This difference in life span is due to differences in rates of senescence. Flies that undergo more rapid senescence have shorter life spans. This project will provide data on the number of genes responsible for differences in life span and senescence between these fly populations. It will also enable identification of the approximate chromosomal locations of these genes. This project will contribute to our understanding of the molecular and genetic basis of aging. Because all animals share many basic similarities at the molecular and cellular levels, this project may provide results that are broadly applicable to the many animal species that undergo aging and senescence, including humans.