Genetic and molecular analysis of the siRNA-mediated gene regulation

siRNA介导的基因调控的遗传和分子分析

• 批准号: RGPIN-2019-06505
• 负责人: Simard, Martin
• 金额: $ 4.23万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=745062
• 关键词: Genetic; molecular; analysis; siRNA; mediated

In the late nineties, the breakthrough discovery of a new way that our cells use to control its materials production have proven once again that biology has yet unexpected things to be found by researchers. Using the round worm as model animal, the discovery of this new cellular pathway called RNA interference or RNAi was acknowledged by the Nobel Committee in 2006 for its real potential in the development of RNAi-related technologies triggers by small molecules called siRNA that are extremely useful for biology research and for industries. Our research group will pursue his research on siRNA-mediated gene regulation using the round worm as a model in order to better understand the details of this biological phenomenom. We believe that our innovative research program will contribute to uncover the importance of siRNAs in biology as well as helping in a better use of RNAi as a molecular technology in research laboratories and in industries.

20世纪90年代末，我们的细胞用来控制其材料生产的一种新方法的突破性发现再次证明，生物学还没有发现研究人员意想不到的东西。2006年，诺贝尔委员会以圆虫为模型动物，承认了这种名为RNA干扰或RNAi的新细胞途径的发现，因为它在开发由称为siRNA的小分子触发的RNAi相关技术方面具有真正的潜力，这些小分子对生物学研究和工业非常有用。为了更好地了解这一生物现象的细节，我们的课题组将以圆蠕虫为模型，继续他对siRNA介导的基因调控的研究。我们相信，我们的创新研究计划将有助于揭示siRNAs在生物学中的重要性，并有助于在研究实验室和工业中更好地使用RNAi作为一种分子技术。