Polyfunctional Organosilanes: New Synthetic Reagents

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The focus of this research is development of organosilyl triflates as precursors for intramolecular Diels-Alder reactions and intramolecular ene reactions. The potential for the methodology will be illustrated by a synthesis of reserpine. With this new award, the Synthetic Organic Program and the Office of Multidisciplinary Activities are supporting the research of Dr. Scott M. Sieburth of the Department of Chemistry at the State University of New York, Stony Brook. Professor Sieburth will focus his work on developing organosilicon methodology which can be used for the synthesis of natural products that have interesting biological properties.