Metal Catalyzed Methods for the Preparation of Organosilanes and Related Reactions

金属催化制备有机硅烷的方法及相关反应

• 批准号: 1800011
• 负责人: Donald Watson
• 金额: $ 47.97万
• 依托单位: University of Delaware
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1800011&HistoricalAwards=false
• 关键词: Metal; Catalyzed; Methods; Preparation; Organosilanes

This award from the Chemical Synthesis Program in the Division of Chemistry supports the work of Professor Donald A. Watson of the University of Delaware. Professor Watson is developing methods that allow for the synthesis of new organic molecules that contain silicon atoms. These types of molecules have broad application to both chemical synthesis and the development of consumer products such as plastics, non-stick coatings, and personal care products. The methodology being pursued by Professor Watson and his students is enabling the synthesis of these important products from simple, cheap, and readily available starting materials. Professor Watson is also developing an integrated undergraduate research program that provides students from underrepresented groups the opportunity to pursue cutting-edge chemical research. This program is allowing students to better connect with their field of study, offering them increased opportunities for mentorship, and developing their research skills so that they can excel in either graduate school or their future employment. In addition, Professor Watson and his research group are engaging in outreach activities that introduce preschool and early school age children to the chemical sciences. Professor Donald A Watson and his research group are examining the use of electrophilic silicon reagents (silyl halides and triflates) with carbon nucleophiles using nickel and palladium catalysis. The Watson group is seeking improved methods for the synthesis of hindered alkyl-, allyl-, and vinyl-silanes using straightforward cross-coupling approaches. The goal of this effort is to increase the scope of these transformations compared to known processes, increase reactivity though the design of new catalytic systems, and to explore the mechanisms of the transformations we develop. Professor Watson and his group are also exploring stereocontrol in these reactions using asymmetric catalysts. In total, this program is leading to new, powerful, and useful methods for organosilane synthesis.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

化学系化学合成项目的这一奖项支持了Donald A.特拉华州大学的沃森说。沃森教授正在开发合成含有硅原子的新有机分子的方法。这些类型的分子在化学合成和消费产品如塑料、不粘涂料和个人护理产品的开发中具有广泛的应用。沃森教授和他的学生所追求的方法是使合成这些重要的产品，从简单，廉价，容易获得的起始材料。沃森教授还开发了一个综合的本科生研究计划，为来自代表性不足的群体的学生提供追求尖端化学研究的机会。该计划允许学生更好地与他们的研究领域联系，为他们提供更多的导师机会，并发展他们的研究技能，使他们能够在研究生院或未来的就业中脱颖而出。此外，沃森教授和他的研究小组正在从事推广活动，介绍学前和学龄前儿童的化学科学。Donald A沃森教授和他的研究小组正在研究使用镍和钯催化的亲电硅试剂（甲硅烷基卤化物和三氟甲磺酸酯）与碳亲核试剂的使用。沃森小组正在寻求使用直接的交叉偶联方法合成受阻烷基-、烯丙基-和乙烯基-硅烷的改进方法。这项工作的目标是增加这些转换的范围相比，已知的方法，增加反应性，通过设计新的催化体系，并探索我们开发的转换机制。沃森教授和他的小组也在探索使用不对称催化剂在这些反应中的立体控制。总的来说，该项目正在为有机硅烷合成带来新的、强大的和有用的方法。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Development of a General Method for the Hiyama-Denmark Cross-Coupling of Tetrasubstituted Vinyl Silanes.

• DOI: 10.1021/acscatal.2c03981
• 发表时间: 2022-10-21
• 期刊: ACS CATALYSIS
• 影响因子: 12.9
• 作者: Pawley, Sarah B.;Conner, Allyssa M.;Omer, Humair M.;Watson, Donald A.
• 通讯作者: Watson, Donald A.

Synthesis of Unsaturated Silyl Heterocycles via an Intramolecular Silyl-Heck Reaction

• DOI: 10.1021/acs.organomet.9b00498
• 发表时间: 2019-10-14
• 期刊: ORGANOMETALLICS
• 影响因子: 2.8
• 作者: Reid, William;McAtee, Jesse R.;Watson, Donald A.
• 通讯作者: Watson, Donald A.

Synthesis of 1,1-Diboryl Alkenes Using the Boryl-Heck Reaction.

• DOI: 10.1021/acs.orglett.1c01567
• 发表时间: 2021-06-18
• 期刊: Organic letters
• 影响因子: 5.2
• 作者: Idowu OO;Hayes JC;Reid WB;Watson DA
• 通讯作者: Watson DA