The Interaction of Bean Alpha-Amylase Inhibitor With Insect Alpha-Amylase

豆α-淀粉酶抑制剂与昆虫α-淀粉酶的相互作用

• 批准号: 9723426
• 负责人: Maarten Chrispeels
• 金额: $ 18万
• 依托单位: University of California-San Diego
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2001-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9723426&HistoricalAwards=false
• 关键词: Interaction; Bean; Alpha; Amylase; Inhibitor

9723426 Chrispeels Based on cloned genes for insect alpha-amylase and bean alpha-amylase inhibitors, the work will use crystallography, biochemical analysis, and site-directed mutagenesis for obtaining a structure model, and an understanding of active site requirements for a productive interaction between the two proteins. Considering the economical importance of crop protection, in this case insect predation of harvested biomass, the work must be rated highly significant from a biotechnological perspective.

9723426 Chrispeels基于昆虫α-淀粉酶和豆类α-淀粉酶抑制剂的克隆基因，这项工作将使用晶体学，生物化学分析和定点诱变来获得结构模型，并了解两种蛋白质之间产生相互作用的活性位点要求。考虑到作物保护的经济重要性，在这种情况下，昆虫捕食收获的生物量，从生物技术的角度来看，这项工作必须被评为非常重要。