Multiplexed Ion Bean Imaging Microscopy to support Digital Pathology in experimental medicine studies

多重离子豆成像显微镜支持实验医学研究中的数字病理学

• 批准号: MR/X012093/1
• 负责人: Christopher Buckley
• 金额: $ 101.94万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FX012093%2F1
• 关键词: Multiplexed; Ion; Bean; Imaging; Microscopy

The most common reason why new treatments to not make it during the early phase drug discovery is that they are not safe but rather that they are not very effective. We now know why. Its due to the unsolved problem of how to show that the drug pathways that the drugs are thought to interfere with have been engaged in the tissues of humans treated with the medicines. We propose that this is because we do not have a sufficiently developed understanding of how to link the drugs being tested to the location of cells in tissues. By using a new type of microscopy called MIBI imaging we aim to provide as disruptive an approach to classical histology as the advent of MRI imaging did for plain film X rays in radiology. We call this new type of histology Digital Pathology and if this grant is funded, we will be the first unit in the UK to have access to the MIBI microscope.

在药物发现的早期阶段，新疗法不能成功的最常见原因是它们不安全，而是不是很有效。我们现在知道原因了。这是由于一个未解决的问题，即如何证明药物被认为会干扰的药物通路已经参与到接受药物治疗的人体组织中。我们认为，这是因为我们对如何将被测试的药物与组织中细胞的位置联系起来还没有充分的了解。通过使用一种称为MIBI成像的新型显微镜，我们的目标是为传统组织学提供一种颠覆性的方法，就像MRI成像在放射学中对X射线平片成像一样。我们称这种新型的组织学为数字病理学，如果这项拨款得到资助，我们将成为英国第一个使用MIBI显微镜的单位。