Multiplexed Ion Bean Imaging Microscopy to support Digital Pathology in experimental medicine studies

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The most common reason why new treatments to not make it during the early phase drug discovery is that they are not safe but rather that they are not very effective. We now know why. Its due to the unsolved problem of how to show that the drug pathways that the drugs are thought to interfere with have been engaged in the tissues of humans treated with the medicines. We propose that this is because we do not have a sufficiently developed understanding of how to link the drugs being tested to the location of cells in tissues. By using a new type of microscopy called MIBI imaging we aim to provide as disruptive an approach to classical histology as the advent of MRI imaging did for plain film X rays in radiology. We call this new type of histology Digital Pathology and if this grant is funded, we will be the first unit in the UK to have access to the MIBI microscope.