General Methods for Catalyst Discovery

化学系的这一启动补助金授予了 位于查佩尔山的北卡罗来纳州支持詹姆斯·P·史密斯教授的研究。 莫肯 本研究的目的是开发一种通用的方法， 通过组合合成技术发现。 中的一项新技术 红外热成像用于同时评估每个 催化剂，在一个大的分子库，为促进的能力， 兴趣的反应。 后续实验解决的能力， 络合金属-配体库以产生用于新化学品的催化剂 转化和热成像分析阐明 用于外消旋起始物的动力学拆分的有效手性催化剂 材料. 这项研究中的技术应用可能使 发现新的催化剂类别， 有效的反应模式。 由于新催化剂的反应性 通过研究，对化学反应性的基本认识是 先进

This starter grant award of the Chemistry Division to the University of North Carolina at Chapel Hill supports the research of Professor James P. Morken. The research aims to develop a general method for catalyst discovery through combinatorial synthetic techniques. A new technique in infrared thermographic imaging is used to evaluate simultaneously each catalyst, in a large molecular library, for the ability to promote a reaction of interest. Follow-on experiments address the ability of complex metal-ligand libraries to yield catalysts for novel chemical transformations and the ability of the thermographic assay to elucidate effective chiral catalysts for the kinetic resolution of racemic starting materials. Application of the technique featured in this research may enable discovery of new classes of catalysts with new, and possibly more effective, modes of reactivity. As the reactivity of new catalysts is investigated, the fundamental understanding of chemical reactivity is advanced.