Exo Selective and Enantioselective Transition-Metal Mediated Cycloaddition Reactions

本研究的重点是钴肟和可沙林的使用 取代的1，3-二烯基络合物的（4 + 2）环加成反应。 对映选择性和外选择性环加成反应的方法学 作为外选择性杂（4 + 2）路线， 开发 所得产物将作为中间体， 含有十氢酮和二氢吡喃的天然产物的构建。 有了这个奖项，有机和高分子化学计划是 支持Mark E博士的研究美国国防部的韦尔克 在维克森林大学读化学。 韦尔克教授将专注于 制定新的方法以编制 使用C-C键形成、环加成反应合成含碳环。 这样形成的产物是制备的重要中间体 具有有趣生物学特性的天然产物。

The focus of this research is the use of cobaloxime and cosalen substituted 1,3-dienyl complexes in (4 + 2) cycloaddition reactions. Methodology for enantio- and exo-selective cycloadditon reactions as well as exo-selective hetero (4 + 2) routes to dihydropyrans will be developed. The resulting products will serve as intermediates for the construction of decalone and dihydropyran containing natural products. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Mark E. Welker of the Department of Chemistry at Wake Forest University. Professor Welker will focus his work on developing new methodology for the preparation of carbon-containing rings using C-C bond forming, cycloaddition reactions. The products thus formed are important intermediates for the preparation of natural products having interesting biological properties.