Exo Selective and Enantioselective Transition-Metal Mediated Cycloaddition Reactions

本研究的重点是在（4 + 2）环加成反应中使用钴胺肟和钴胺取代的1,3-二烯基配合物。对映和外选择性环加成反应以及外选择性异（4 + 2）途径生成二氢吡喃的方法将得到发展。所得产物将作为构建含癸酮和二氢吡喃天然产物的中间体。通过这个奖项，有机和大分子化学项目支持了维克森林大学化学系马克·e·威尔克博士的研究。Welker教授将专注于开发新的方法，利用C-C键形成环加成反应制备含碳环。由此形成的产物是制备具有有趣生物学特性的天然产物的重要中间体。

The focus of this research is the use of cobaloxime and cosalen substituted 1,3-dienyl complexes in (4 + 2) cycloaddition reactions. Methodology for enantio- and exo-selective cycloadditon reactions as well as exo-selective hetero (4 + 2) routes to dihydropyrans will be developed. The resulting products will serve as intermediates for the construction of decalone and dihydropyran containing natural products. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Mark E. Welker of the Department of Chemistry at Wake Forest University. Professor Welker will focus his work on developing new methodology for the preparation of carbon-containing rings using C-C bond forming, cycloaddition reactions. The products thus formed are important intermediates for the preparation of natural products having interesting biological properties.