New biocatalysts for selective chemical oxidations under extreme conditions

用于极端条件下选择性化学氧化的新型生物催化剂

• 批准号: DP240101500
• 负责人: A/Prof Stephen Bell
• 金额: $ 54.49万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240101500
• 关键词: New; biocatalysts; selective; chemical; oxidations

This project will identify and design new enzyme biocatalysts which function under extreme conditions such as elevated temperature and high concentrations of peroxides. These enzymes will be sourced from microorganisms which are located in extreme biological environments e.g. hot springs (the so-called extremophiles). The expected outcome of this project are the identification of robust enzymes which can catalyse selective oxidation reactions in complex organic molecules, such as steroids. The new biocatalysts developed in this project will have significant benefit in the development of new routes to access bespoke molecules of value in fine chemical synthesis and drug development.

该项目将确定和设计新的酶生物催化剂，这些催化剂在极端条件下发挥作用，如高温和高浓度的过氧化氢。这些酶将来自极端生物环境中的微生物，例如温泉(所谓的极端微生物)。该项目的预期结果是鉴定出能够在复杂有机分子(如类固醇)中催化选择性氧化反应的强健酶。在该项目中开发的新生物催化剂将在开发新的途径以获得在精细化学合成和药物开发中有价值的定制分子方面具有重要意义。