U.S.-France Cooperative Research: Molecular Basis of Endothelial Mechanics and Adhesion

这个为期三年的奖项为美法合作研究提供支持，研究机械力对内皮细胞分子事件的影响，以及白细胞与内皮细胞的相互作用。内皮细胞排列在血管、淋巴管、心脏和其他腔体的内部。此次合作包括加州大学圣地亚哥分校的钱树和法国南锡洛林国立理工学院的王雄的研究小组。目的是阐明二次流和流动分离对血管内皮细胞信号转导和基因表达的影响，探讨白细胞对内皮细胞滚动的分子生物力学基础。美国研究小组为这次合作带来了血管细胞中机械力和基因调控耦合的专业知识。这是由法国在生物流变学方面的专业知识补充。该项目将促进对机械化学转导和细胞-细胞相互作用的基本生物学过程的理解。

This three-year award provides support for US-France cooperative research on the effects of mechanical forces on molecular events in endothelial cells, and leukocyte-endothelial interactions. Endothelial cells line the inside of blood and lymph vessels, the heart and other cavities. The collaboration involves the research group of Shu Chien of the University of California, San Diego and Xiong Wang of the National Polytechnic Institute of Lorraine in Nancy, France. The objectives are to elucidate the effects of secondary flow and flow separation on signal transduction and gene expression in vascular endothelial cells, and to investigate the molecular biomechanical basis for rolling of leukocytes on endothelial cells. The US research group brings to this collaboration expertise on the coupling of mechanical forces and gene regulation in vascular cells. This is complemented by French expertise in biorheology. The project will advance understanding of the fundamental biological processes of mechanochemical transduction and cell-cell interaction.