Magnetic Tweezers
磁性镊子
基本信息
- 批准号:9730999
- 负责人:
- 金额:$ 2.41万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:1998
- 资助国家:美国
- 起止时间:1998-09-15 至 2001-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This grant will support the development of a magnetic tweezers apparatus to measure local viscoelastic and structural properties of the cell cytoplasm and the extracellular matrix. The magnetic tweezers produce a magnetic field of known magnitude and direction. The field exerts a magnetic force on spherical magnetic particles with definite geometric and magnetic properties, which are injected into the cytoplasm or matrix. The motion of the magnetic particle is monitored using optical methods. The trajectory of the particle is recorded on a computer. Simultaneously, the motion of the particle is also described in terms of standard models. The local viscoelastic parameters of the cytoplasm or matrix are obtained from the matching of the model trajectory and the experimentally obtained trajectory. The knowledge of these parameters provides information on the local structure of interconnected networks of biological macromolecules that exist in the cytoplasm (i.e. cytoskeleton) and the extracellular matrix. The magnetic tweezers will also be used to study intracellular stress propagation. At present the magnetic tweezers are the only apparatus that allows the measurement of local viscoelastic properties of biological systems in a non-destructive way. By combining several magnetic tweezers, effects similar to those produced by optical tweezers could be generated. The laser traps in the latter case are analogous to magnetic traps in the former case. At the same time, the costs associated with the development and operation of a magnetic tweezers are significantly lower.
这笔赠款将支持开发磁镊仪,以测量细胞质和细胞外基质的局部粘弹性和结构特性。磁性镊子产生已知大小和方向的磁场。磁场对具有一定几何和磁性的球形磁性颗粒施加磁力,将其注入细胞质或基质中。用光学方法监测磁粉的运动。粒子的轨迹被记录在计算机上。同时,粒子的运动也用标准模型来描述。通过模型轨迹与实验轨迹的匹配,得到细胞质或基质的局部粘弹性参数。对这些参数的了解提供了存在于细胞质(即细胞骨架)和细胞外基质中的生物大分子互联网络的局部结构的信息。磁镊子也将被用来研究细胞内的应力传播。目前,磁镊子是唯一能够以非破坏性方式测量生物系统局部粘弹性性质的仪器。通过组合几个磁镊子,可以产生类似于光学镊子产生的效果。后一种情况下的激光陷阱类似于前一种情况下的磁陷阱。同时,与磁镊子的开发和操作相关的成本显著降低。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Gabor Forgacs其他文献
The emerging trend of hotel total revenue management
- DOI:
10.1057/s41272-016-0057-x - 发表时间:
2016-09-24 - 期刊:
- 影响因子:1.500
- 作者:
Chuyi Zheng;Gabor Forgacs - 通讯作者:
Gabor Forgacs
Biological Physics of the Developing Embryo: Introduction: Biology and physics
胚胎发育的生物物理学:简介:生物学和物理学
- DOI:
10.1017/cbo9780511755576.001 - 发表时间:
2005 - 期刊:
- 影响因子:19
- 作者:
Gabor Forgacs;Stuart A. Newman - 通讯作者:
Stuart A. Newman
Biological Physics of the Developing Embryo: Fertilization: generating one living dynamical system from two
胚胎发育的生物物理学:受精:从两个生命动力系统产生一个生命动力系统
- DOI:
10.1017/cbo9780511755576.010 - 发表时间:
2005 - 期刊:
- 影响因子:0.7
- 作者:
Gabor Forgacs;Stuart A. Newman - 通讯作者:
Stuart A. Newman
How Phosphatidylinositol 4,5-bisphosphate Regulates Membrane-Cytoskeleton Interaction in Endothelial Cells?
- DOI:
10.1016/j.bpj.2008.12.2009 - 发表时间:
2009-02-01 - 期刊:
- 影响因子:
- 作者:
Zhongkui Hong;Marius Staiculescu;Mingzhai Sun;Irena Levitan;Gabor Forgacs - 通讯作者:
Gabor Forgacs
Effective Lifetime Of Membrane Tethers Formed By Multiple Contacts Obeys A Generalized Bell Model
- DOI:
10.1016/j.bpj.2008.12.1795 - 发表时间:
2009-02-01 - 期刊:
- 影响因子:
- 作者:
Marius C. Staiculescu;Mingzhai Sun;Imre Derenyi;Gabor Forgacs - 通讯作者:
Gabor Forgacs
Gabor Forgacs的其他文献
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{{ truncateString('Gabor Forgacs', 18)}}的其他基金
2010 International Conference on Biofabrication: October 4-6, 2010 in Philadelphia, PA
2010 年生物制造国际会议:2010 年 10 月 4-6 日在宾夕法尼亚州费城举行
- 批准号:
1010335 - 财政年份:2010
- 资助金额:
$ 2.41万 - 项目类别:
Standard Grant
Regenerative Technologies in the Future: Tissue Engineering and Organ Printing
未来的再生技术:组织工程和器官打印
- 批准号:
0810261 - 财政年份:2008
- 资助金额:
$ 2.41万 - 项目类别:
Standard Grant
FIBR: Understanding Multicellular Self-Assembly
FIBR:了解多细胞自组装
- 批准号:
0526854 - 财政年份:2005
- 资助金额:
$ 2.41万 - 项目类别:
Continuing Grant
U.S. - Hungary Workshop on Models of Biological Motion
美国-匈牙利生物运动模型研讨会
- 批准号:
9988631 - 财政年份:2000
- 资助金额:
$ 2.41万 - 项目类别:
Standard Grant
Computerized Freshman Physics Laboratories: Learning ThroughApplications and Open-Ended Problems
计算机化新生物理实验室:通过应用程序和开放式问题进行学习
- 批准号:
9850687 - 财政年份:1998
- 资助金额:
$ 2.41万 - 项目类别:
Standard Grant
COLLABORATIVE PROJECT: Physical Mechanisms of Morphogenesis
合作项目:形态发生的物理机制
- 批准号:
9710010 - 财政年份:1997
- 资助金额:
$ 2.41万 - 项目类别:
Standard Grant
Les Houches Winter School (Workshop) on: Interplay of Genetic and Physical Processes in the Development of Biological Form February 20-26, 1994, Les Houches, France
里苏什冬季学校(研讨会):生物形态发展中遗传和物理过程的相互作用 1994 年 2 月 20-26 日,法国里苏什
- 批准号:
9320221 - 财政年份:1994
- 资助金额:
$ 2.41万 - 项目类别:
Standard Grant
Collaborative Project: Physical Mechanisms of Morphogenesis
合作项目:形态发生的物理机制
- 批准号:
9317933 - 财政年份:1993
- 资助金额:
$ 2.41万 - 项目类别:
Continuing Grant
Les Houches Winter School on "Dynamical Processes at Interfaces, Surfaces and Membranes", Les Houches, France, February 19-28, 1991
里苏什冬季学校“界面、表面和膜的动态过程”,法国里苏什,1991 年 2 月 19-28 日
- 批准号:
9021422 - 财政年份:1991
- 资助金额:
$ 2.41万 - 项目类别:
Standard Grant
相似国自然基金
基于“3D-Tweezers”冷冻金探针和深度学习识别的农产品中真菌毒素快速检测技术研究
- 批准号:
- 批准年份:2021
- 资助金额:55 万元
- 项目类别:面上项目
相似海外基金
Unveiling Functionally Critical, Ephemeral RNA (un)folding States with Magnetic Tape Head Tweezers
使用磁带头镊子揭示功能关键的短暂 RNA(解)折叠状态
- 批准号:
2140320 - 财政年份:2021
- 资助金额:
$ 2.41万 - 项目类别:
Standard Grant
Design and implementation of novel magnetic tweezers devices for force application on micro and nano scaled biological systems with precise temporal and patterned 3-dimensional spatial resolution.
设计和实现新型磁性镊子装置,用于在微米级和纳米级生物系统上施加力,具有精确的时间和图案化的 3 维空间分辨率。
- 批准号:
454094-2014 - 财政年份:2016
- 资助金额:
$ 2.41万 - 项目类别:
Postgraduate Scholarships - Doctoral
Design and implementation of novel magnetic tweezers devices for force application on micro and nano scaled biological systems with precise temporal and patterned 3-dimensional spatial resolution.
设计和实现新型磁性镊子装置,用于在微米级和纳米级生物系统上施加力,具有精确的时间和图案化的 3 维空间分辨率。
- 批准号:
454094-2014 - 财政年份:2015
- 资助金额:
$ 2.41万 - 项目类别:
Postgraduate Scholarships - Doctoral
Design and implementation of novel magnetic tweezers devices for force application on micro and nano scaled biological systems with precise temporal and patterned 3-dimensional spatial resolution.
设计和实现新型磁性镊子装置,用于在微米级和纳米级生物系统上施加力,具有精确的时间和图案化的 3 维空间分辨率。
- 批准号:
454094-2014 - 财政年份:2014
- 资助金额:
$ 2.41万 - 项目类别:
Postgraduate Scholarships - Doctoral
Development of Next Generation Magnetic Tweezers for the Study of the Mechanical Properties of the Cytoskeleton in Cells.
开发下一代磁性镊子,用于研究细胞中细胞骨架的机械特性。
- 批准号:
438464-2013 - 财政年份:2013
- 资助金额:
$ 2.41万 - 项目类别:
Postgraduate Scholarships - Master's
FIRCA: Probing the Nucleus- Cytoskeleton Connection Using Magnetic Tweezers
FIRCA:使用磁镊探测细胞核-细胞骨架连接
- 批准号:
8462715 - 财政年份:2011
- 资助金额:
$ 2.41万 - 项目类别:
FIRCA: Probing the Nucleus- Cytoskeleton Connection Using Magnetic Tweezers
FIRCA:使用磁镊探测细胞核-细胞骨架连接
- 批准号:
8274428 - 财政年份:2011
- 资助金额:
$ 2.41万 - 项目类别:
FIRCA: Probing the Nucleus- Cytoskeleton Connection Using Magnetic Tweezers
FIRCA:使用磁镊探测细胞核-细胞骨架连接
- 批准号:
8080552 - 财政年份:2011
- 资助金额:
$ 2.41万 - 项目类别:
Characterization of torque on DNA in a magnetic tweezers instrument
磁力镊子仪器中 DNA 扭矩的表征
- 批准号:
367332-2008 - 财政年份:2008
- 资助金额:
$ 2.41万 - 项目类别:
University Undergraduate Student Research Awards
Imaginary Magnetic Tweezers for Biophysical Force Measurements
用于生物物理力测量的假想磁力镊子
- 批准号:
0625480 - 财政年份:2006
- 资助金额:
$ 2.41万 - 项目类别:
Standard Grant