SBIR Phase I: Nonporous Zirconia for Ultrafast Analytical Chromatography

这个小型企业创新研究一期项目将测试合成单分散、无孔氧化锆微球的可行性，该微球用于高效液相色谱（HPLC）分析对环境有影响的物质。目前的高效液相色谱法在除草剂和农药的分析中存在速度和分辨率的限制，并且由于其多孔性和不耐高温，需要大量的溶剂。无孔氧化锆，通过CVD与碳涂层，将克服这些问题。这些氧化锆微球（直径约1微米）将用烷氧锆和锆盐合成。主要目的是提供无孔单分散球形氧化锆颗粒来生产超快色谱柱，但颗粒合成工作也将有益于其他行业，如陶瓷合成和催化。这项研究的主要商业效益将是减少对环境有影响的物质的反相色谱分离中使用的有机溶剂。* * *

*** 9761543 McNeff This Small Business Innovation Research Phase I project will test the feasibility of synthesizing monodisperse, nonporous zirconia microspheres for use as high performance liquid chromatography (HPLC) supports for the analysis of environmentally-impactive substances. Current HPLC supports limit speed and resolution in the analysis of herbicides and pesticides, and require large amounts of solvent, because they are porous and cannot tolerate high temperature. Nonporous zirconia, coated by CVD with carbon, will overcome these problems. These zirconia microspheres (ca. 1 micrometer in diameter) will be synthesized using zirconium alkoxides and zirconium salts. The primary objective is to provide nonporous monodisperse spherical zirconia particles to produce ultrafast chromatography columns, but the particle synthesis work will also benefit other industries e.g. ceramic synthesis and catalysis. The primary commercial benefit of this research will be the reduction of organic solvent used in reversed-phase chromatographic separations of environmentally impactive substances. ***