SBIR Phase I: Nonporous Zirconia for Ultrafast Analytical Chromatography

*9761543麦克内夫这个小型企业创新研究第一阶段项目将测试合成单分散、无孔氧化锆微球的可行性，以用作环境影响物质分析的高效液相色谱载体。目前的高效液相色谱法在除草剂和农药的分析中支持有限的速度和分辨率，并且需要大量的溶剂，因为它们是多孔的，不能耐高温。在CVD表面涂上一层碳的无孔氧化锆将克服这些问题。这些氧化锆微球(直径约1微米)将由醇酸锆盐和锆盐合成。其主要目标是为生产超快色谱柱提供无孔、单分散的球形氧化锆颗粒，但颗粒合成工作也将有益于其他行业，如陶瓷合成和催化。这项研究的主要商业利益将是减少反相色谱分离环境影响物质所使用的有机溶剂。***

*** 9761543 McNeff This Small Business Innovation Research Phase I project will test the feasibility of synthesizing monodisperse, nonporous zirconia microspheres for use as high performance liquid chromatography (HPLC) supports for the analysis of environmentally-impactive substances. Current HPLC supports limit speed and resolution in the analysis of herbicides and pesticides, and require large amounts of solvent, because they are porous and cannot tolerate high temperature. Nonporous zirconia, coated by CVD with carbon, will overcome these problems. These zirconia microspheres (ca. 1 micrometer in diameter) will be synthesized using zirconium alkoxides and zirconium salts. The primary objective is to provide nonporous monodisperse spherical zirconia particles to produce ultrafast chromatography columns, but the particle synthesis work will also benefit other industries e.g. ceramic synthesis and catalysis. The primary commercial benefit of this research will be the reduction of organic solvent used in reversed-phase chromatographic separations of environmentally impactive substances. ***