SBIR Phase I: Nonporous Zirconia for Ultrafast Analytical Chromatography

SBIR 第一阶段：用于超快分析色谱的无孔氧化锆

• 批准号: 9761543
• 负责人: Clayton McNeff
• 金额: $ 10万
• 依托单位: ZirChrom Separations, Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-01-01 至 1998-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9761543&HistoricalAwards=false
• 关键词: SBIR; Phase; Nonporous; Zirconia; Ultrafast

*** 9761543 McNeff This Small Business Innovation Research Phase I project will test the feasibility of synthesizing monodisperse, nonporous zirconia microspheres for use as high performance liquid chromatography (HPLC) supports for the analysis of environmentally-impactive substances. Current HPLC supports limit speed and resolution in the analysis of herbicides and pesticides, and require large amounts of solvent, because they are porous and cannot tolerate high temperature. Nonporous zirconia, coated by CVD with carbon, will overcome these problems. These zirconia microspheres (ca. 1 micrometer in diameter) will be synthesized using zirconium alkoxides and zirconium salts. The primary objective is to provide nonporous monodisperse spherical zirconia particles to produce ultrafast chromatography columns, but the particle synthesis work will also benefit other industries e.g. ceramic synthesis and catalysis. The primary commercial benefit of this research will be the reduction of organic solvent used in reversed-phase chromatographic separations of environmentally impactive substances. ***

*** 9761543 麦克内夫 这个小企业创新研究第一阶段项目将测试合成单分散，无孔氧化锆微球的可行性，用作高效液相色谱（HPLC）支持环境影响物质的分析。 目前的HPLC在除草剂和杀虫剂的分析中支持有限的速度和分辨率，并且需要大量的溶剂，因为它们是多孔的并且不能耐受高温。 无孔氧化锆，通过CVD与碳涂层，将克服这些问题。这些氧化锆微球（ca. 1微米直径）将使用锆醇盐和锆盐合成。 主要目标是提供无孔单分散球形氧化锆颗粒以生产超快色谱柱，但颗粒合成工作也将使其他行业受益，例如陶瓷合成和催化。 这项研究的主要商业效益将是减少对环境有影响的物质的反相色谱分离中使用的有机溶剂。 ***