Symposium: Subtypes of Muscarinic Receptors, Danvers, MA, August 25 - 29, 1998

Lay概要建议IBN 98-01873“会议：M受体亚型研讨会”Ruth Levine，P.I.该奖项是对一个关于在活神经膜的复杂分子中发现的形式和功能多样性的国际会议的部分支持，肌肉和其他由神经系统控制的细胞。神经细胞之间的功能性接触称为突触，在突触的细胞之间传递信号的生化化合物称为神经递质。递质分子被称为受体的分子捕获在靶细胞的细胞膜表面。某些种类的递质，如特定的氨基酸或特定的儿茶酚胺化合物，已知具有特定的受体类型，可以在突触后细胞中触发特定的反应。最近，受体分子的亚型被发现，通常具有不同的化学结合亲和力、分子排列和偶联机制。这次研讨会在分子水平上介绍了在了解称为M受体的特定受体亚型方面的最新进展，M受体调节神经和肌肉细胞对一种名为乙酰胆碱的广泛神经递质的反应。该计划将把对这些受体感兴趣的知名学者和初级科学家聚集在一起，使他们能够交换关于这些重要分子的数据和最新想法。这样的目标对于我们逐步更好地理解大脑和有机体的身体是怎样的很重要。支持是帮助支付外地年轻研究人员的一些旅费，使他们能够出席这次会议并提交自己的研究成果。这种支持将对促进年轻神经科学家的职业发展产生影响，研讨会的演讲将对肌肉和心血管研究以及神经科学产生影响。

LAY SUMMARY Proposal IBN 98-01873 "CONFERENCE: Symposium on subtypes of muscarinic receptors" Ruth Levine, P.I. This award is for partial support of an international conference on the diversity of form and function found among complex molecules of the membrane of living nerve, muscle and other cells controlled by the nervous system. The functional contacts between nerve cells are called synapses, and the biochemical compounds that carry signals between the cells at the synapse are called neurotransmitters. The transmitter molecules are captured on the surface of the cell membrane of the target cell by molecules called receptors. Classes of transmitters, like particular amino acids, or particular catecholamine compounds, were known to have particular receptor types that triggered particular responses in the post-synaptic cell. More recently, subtypes of receptor molecules have been found, often with different chemical binding affinities, molecular arrangement, and coupling mechanisms. This symposium covers recent advances at the molecular level in understanding the subtypes of the particular receptors called muscarinic receptors, which modulate the responses of nerve and muscle cells to a widespread neurotransmitter called acetylcholine. The program will bring together eminent scholars and junior scientists with interests in these receptors, to allow them to exchange data and the latest ideas on these important molecules. Such goals are important to our progressively better understanding of how the brain an organism's body. Support is to help cover some travel costs of young investigators in the field to enable them to attend and deliver their own research results at this meeting. This support will have an impact on fostering the career development of young neuroscientists, and t he symposium presentations will have an impact on muscle and cardiovascular research as well as neuroscience.