Symposium: Subtypes of Muscarinic Receptors, Danvers, MA, August 25 - 29, 1998

“会议：毒蕈碱受体亚型研讨会”Ruth Levine， P.I.该奖项是为了部分支持一个关于在活神经、肌肉和其他受神经系统控制的细胞的膜的复杂分子中发现的形式和功能多样性的国际会议。神经细胞之间的功能性联系被称为突触，在突触细胞之间传递信号的生化化合物被称为神经递质。发射器分子被称为受体的分子捕获在靶细胞的细胞膜表面。各类递质，如特定的氨基酸，或特定的儿茶酚胺化合物，已知有特定的受体类型，在突触后细胞中触发特定的反应。最近，受体分子的亚型被发现，通常具有不同的化学结合亲和力，分子排列和偶联机制。本次研讨会涵盖了在分子水平上理解特定受体毒蕈碱受体亚型的最新进展，毒蕈碱受体调节神经和肌肉细胞对广泛存在的神经递质乙酰胆碱的反应。该项目将汇集对这些受体感兴趣的知名学者和初级科学家，让他们就这些重要分子交换数据和最新想法。这样的目标对于我们逐渐更好地理解大脑是如何构成有机体的身体是很重要的。支持是帮助支付该领域年轻研究人员的一些旅费，使他们能够出席会议并在会议上发表自己的研究成果。这种支持将对培养年轻神经科学家的职业发展产生影响，研讨会的演讲将对肌肉和心血管研究以及神经科学产生影响。

LAY SUMMARY Proposal IBN 98-01873 "CONFERENCE: Symposium on subtypes of muscarinic receptors" Ruth Levine, P.I. This award is for partial support of an international conference on the diversity of form and function found among complex molecules of the membrane of living nerve, muscle and other cells controlled by the nervous system. The functional contacts between nerve cells are called synapses, and the biochemical compounds that carry signals between the cells at the synapse are called neurotransmitters. The transmitter molecules are captured on the surface of the cell membrane of the target cell by molecules called receptors. Classes of transmitters, like particular amino acids, or particular catecholamine compounds, were known to have particular receptor types that triggered particular responses in the post-synaptic cell. More recently, subtypes of receptor molecules have been found, often with different chemical binding affinities, molecular arrangement, and coupling mechanisms. This symposium covers recent advances at the molecular level in understanding the subtypes of the particular receptors called muscarinic receptors, which modulate the responses of nerve and muscle cells to a widespread neurotransmitter called acetylcholine. The program will bring together eminent scholars and junior scientists with interests in these receptors, to allow them to exchange data and the latest ideas on these important molecules. Such goals are important to our progressively better understanding of how the brain an organism's body. Support is to help cover some travel costs of young investigators in the field to enable them to attend and deliver their own research results at this meeting. This support will have an impact on fostering the career development of young neuroscientists, and t he symposium presentations will have an impact on muscle and cardiovascular research as well as neuroscience.