Dissertation Enhancement: Crystallographic Studies of the Flavoprotein NADH Oxidase, A Key Enzyme in Streptococcal Energy Metabolism

论文增强：黄素蛋白 NADH 氧化酶（链球菌能量代谢中的关键酶）的晶体学研究

• 批准号: 9803674
• 负责人: H. Alexander Claiborne
• 金额: $ 2.4万
• 依托单位: Wake Forest University School of Medicine
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 1999-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9803674&HistoricalAwards=false
• 关键词: Dissertation; Enhancement; Crystallographic; Studies; Flavoprotein

9803674 Claiborne This award will support Mr. Conn Mallett, a Ph.D. student under Professor Al Claiborne at Wake Forest University, to conduct dissertation research in collaboration with Professor Tomitake Tsukihara of the Institute for Protein Research, Osaka University, Japan. Mr. Mallett will spend 12 months working in Japan on crystallographic studies focused on the structure of the flavoprotein NADH oxidase, a key enzyme in streptococcal energy metabolism. Use of the host institute's macromolecular crystallography facility will provide structural information which will complement current studies on the kinetic and redox properties of the enzyme. This research will add to our fundamental understanding of flavoprotein structure and function, and offers the potential for application of structural information to the design of new therapeutic molecules for fighting streptococcal infection in humans. Moreover, this project enables collaboration between complementary laboratories in the United States and Japan and provides international research experience for an American graduate student. ***

9803674 Claiborne 该奖项将支持 Conn Mallett 先生，他是一名博士。维克森林大学 Al Claiborne 教授的学生，与日本大阪大学蛋白质研究所的 Tomitake Tsukihara 教授合作进行论文研究。 Mallett 先生将在日本工作 12 个月，从事晶体学研究，重点研究黄素蛋白 NADH 氧化酶的结构，黄素蛋白 NADH 氧化酶是链球菌能量代谢的关键酶。 使用主办研究所的大分子晶体学设施将提供结构信息，这将补充当前关于酶的动力学和氧化还原特性的研究。 这项研究将增进我们对黄素蛋白结构和功能的基本理解，并为应用结构信息设计抗人类链球菌感染的新治疗分子提供潜力。 此外，该项目还实现了美国和日本互补实验室之间的合作，并为美国研究生提供了国际研究经验。 ***