Japan JSPS Program: Enantioselective Total Synthesis of (+)- Catharanthine

日本JSPS计划：( )-长春质的对映选择性全合成

• 批准号: 9803688
• 负责人: Eric Zylstra
• 金额: $ 0.3万
• 依托单位: Fellowships
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-15 至 2000-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9803688&HistoricalAwards=false
• 关键词: Japan; JSPS; Program; Enantioselective; Total

Zylstra 9803688 This award supports a 24 month Japan Society for the Promotion of Science (JSPS) Postdoctoral Fellowship for Dr. Eric Zylstra at the University of Tokyo in Japan. Dr. Zylstra will work with Dr. Tohru Fukuyama, Professor, Faculty of Pharmaceutical Sciences, University of Tokyo on a research project entitled "Enantioselective Total Synthesis of Vinblastine." The proposed research will provide a direct, efficient route to the antitumor drug vinblastine. Although this compound has a long history of use in chemotherapy, its structural complexity hinders the preparation of analogs. One commonly chosen synthetic strategy toward vinblastine is the coupling of catharanthine or a catharanthine-like precursor with the structurally-related compound vindoline. Investigations will be undertaken on the usefulness of some novel palladium methodology for assembling the vinblastine skeleton. This should lead to development of a more direct, efficient route to its synthesis making it, and structurally similar analogs, more readily available for the preparation of new, more potent vinblastine analogs. ***

Zylstra 9803688 该奖项支持日本东京大学Eric Zylstra博士为期24个月的日本科学促进会（JSPS）博士后研究金。 Zylstra博士将与东京大学药学系教授Tohru Fukuyama博士合作开展一项名为“长春碱的对映选择性全合成”的研究项目。" 该研究将为抗肿瘤药物长春碱的合成提供一条直接、有效的途径。 虽然这种化合物在化疗中有很长的使用历史，但其结构复杂性阻碍了类似物的制备。 长春碱的一种通常选择的合成策略是长春质碱或长春质碱样前体与结构相关的化合物文多灵的偶联。 调查将进行一些新的钯组装长春碱骨架的方法的有用性。 这将导致开发一种更直接、更有效的合成途径，使其与结构相似的类似物更容易用于制备新的、更有效的长春碱类似物。 ***