Japan JSPS Program: Enantioselective Total Synthesis of (+)- Catharanthine

日本JSPS计划：( )-长春质的对映选择性全合成

• 批准号: 9803688
• 负责人: Eric Zylstra
• 金额: $ 0.3万
• 依托单位: Fellowships
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-15 至 2000-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9803688&HistoricalAwards=false
• 关键词: Japan; JSPS; Program; Enantioselective; Total

Zylstra 9803688 This award supports a 24 month Japan Society for the Promotion of Science (JSPS) Postdoctoral Fellowship for Dr. Eric Zylstra at the University of Tokyo in Japan. Dr. Zylstra will work with Dr. Tohru Fukuyama, Professor, Faculty of Pharmaceutical Sciences, University of Tokyo on a research project entitled "Enantioselective Total Synthesis of Vinblastine." The proposed research will provide a direct, efficient route to the antitumor drug vinblastine. Although this compound has a long history of use in chemotherapy, its structural complexity hinders the preparation of analogs. One commonly chosen synthetic strategy toward vinblastine is the coupling of catharanthine or a catharanthine-like precursor with the structurally-related compound vindoline. Investigations will be undertaken on the usefulness of some novel palladium methodology for assembling the vinblastine skeleton. This should lead to development of a more direct, efficient route to its synthesis making it, and structurally similar analogs, more readily available for the preparation of new, more potent vinblastine analogs. ***

Zylstra 9803688该奖项为日本东京大学的Eric Zylstra博士促进科学促进学会（JSPS）24个月的促进学会（JSPS）。 Zylstra博士将与东京大学药学学院教授Tohru Fukuyama博士合作。 拟议的研究将为抗肿瘤药物葡萄蛋白提供直接，有效的途径。 尽管该化合物在化学疗法中具有悠久的使用史，但其结构复杂性阻碍了类似物的制备。 一种通常选择的葡萄碱的合成策略是catharanthine或类似凝视蛋白的前体与结构相关的化合物Vindoline的偶联。 将研究一些新型钯方法来组装长质骨骼的有用性。 这应该导致发展其合成的更直接，有效的途径，并在结构上类似的类似物中发展，更容易地用于制备新的，更有效的vinblastine类似物。 ***