FASEB Conference: Intracellular RNA Sorting, Transport and Localization, to be held in Snowmass, Colorado, June 6-11, 1998

9805557该奖项为FASE B会议提供部分支持，该会议侧重于转录后核糖核酸加工、运输和靶向等多学科领域。由于集中研究各种分子、细胞和发育问题的信息，这一领域的重要性已变得显而易见。在过去的15年里，在脊椎动物和无脊椎动物的各种细胞类型中，从卵母细胞到上皮细胞，再到神经元和神经胶质细胞，已经发现了70多个细胞内定位的RNA。此外，不同种类的蛋白质由定位的RNA编码，包括转录因子、RNA结合蛋白、细胞骨架蛋白、细胞内信号分子和分泌型生长因子。现在已经很清楚，靶向特定细胞内位置的mRNAs在生物过程中起着关键作用，包括建立卵母细胞的极性、早期胚胎分化、体细胞极化和功能、突触生长和脊椎动物神经系统的可塑性。会议的目标是在1994年和1996年举行的两次类似和成功的会议的基础上，将这一领域具有广泛观点和背景的研究人员和学生聚集在一起。会议将探讨共同的主题和问题，包括(1)RNA定位在建立胚胎细胞谱系和细胞极性中的作用，(2)靶向特定细胞内位置的顺式作用信号和反式作用因子，(3)负责这种靶向的递送系统，(4)在靶点锚定mRNAs的机制，(5)靶点的特征和范围，(6)细胞外和细胞内信号系统在RNA运输和靶向中的参与，(7)跨核膜的RNA运输，(8)RNA分选对细胞功能的影响。很大一部分会议资源将用于支持研究生和年轻研究人员的出席。

9805557 The award provides partial support for a FASEB Conference that focuses on the multidisciplinary area of post-transcriptional RNA processing, transport and targeting. The importance of this area has become evident as a result of the convergence of information from studies focusing on a variety of molecular, cellular and developmental questions. During the past fifteen years over seventy intracellularly localized RNAs have been identified in a diversity of cell types in both vertebrates and invertebrates, ranging from oocytes to epithelial cells to neurons and glia. In addition, diverse classes of proteins are encoded by localized RNAs, including transcription factors, RNA binding proteins, cytoskeletal proteins, intracellular signaling molecules and secreted growth factors. It is now clear that the targeting of mRNAs to particular intracellular locations plays a key role in biological processes that include the establishment of oocyte polarity, early embryonic differentiation, somatic cell polarization and function, synapse growth, and plasticity in the vertebrate nervous system. The goal of the conference is to build upon two similar and successful conferences held in 1994 and 1996 by bringing together researchers and students with a wide range of perspectives and backgrounds in this area. The conference will explore common themes and questions that include (1) the role of RNA localization in establishment of embryonic cell lineage and cell polarity, (2) cis-acting signals and trans-acting factors that target mRNAs to specific intracellular locations, (3) the delivery systems responsible for this targeting, (4) the mechanism that anchors mRNAs at target locations, (5) the characterization and extent of targeting sites, (6) the involvement of extracellular and intracellular signaling systems in mRNA transport and targeting, (7) transport of RNA across the nuclear envelope, and (8) the effects of RNA sorting on cell functions. A significan t portion of conference resources will be used to support the attendance of graduate students and young investigators.